Exploring the mechanism of radiation-enhanced hepatocellular carcinoma cell invasion by swept source optical coherence tomography

W. C. Kuo, W. W. Cheng, C. H. Chou, J. C.H. Cheng

研究成果: Conference contribution同行評審

2 引文 斯高帕斯(Scopus)

摘要

Ionizing radiation is a standard treatment for various human solid tumors. However, several clinical studies showed that a significant proportion of patients undergoing radiotherapy for hepatocellular carcinoma (HCC) develop intrahepatic and extrahepatic metastasis. Understanding of radiation-induced cancer cell invasiveness and behavior is essential and of great important for developing suitable treatment strategies to contain cancer spread. Therefore, in this study we evaluated the effectiveness of using swept source optical coherence tomography (SS-OCT) to monitor the enhancement of HCC cell invasiveness by radiation. SS-OCT images were acquired and recorded to obtain three-dimensional data sets per four hours in 48 hours after irradiating HepG2 cells with 7.5 Gy. The cell migration behavior in three-dimensional tissue models was quantified from images of radiation-induced and sham-irradiated cells.

原文English
主出版物標題Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XV
DOIs
出版狀態Published - 2011
事件Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XV - San Francisco, CA, United States
持續時間: 24 1月 201126 1月 2011

出版系列

名字Progress in Biomedical Optics and Imaging - Proceedings of SPIE
7889
ISSN(列印)1605-7422

Conference

ConferenceOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XV
國家/地區United States
城市San Francisco, CA
期間24/01/1126/01/11

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