Evolution of the yeast protein interaction network

Hong Qint, Henry H.S. Lu, Wei B. Wu, Wen Hsiung Li*

*此作品的通信作者

研究成果: Article同行評審

59 引文 斯高帕斯(Scopus)

摘要

To study the evolution of the yeast protein interaction network, we first classified yeast proteins by their evolutionary histories into isotemporal categories, then analyzed the interaction tendencies within and between the categories, and finally reconstructed the main growth path. We found that two proteins tend to interact with each other if they are in the same or similar categories, but tended to avoid each other otherwise, and that network evolution mirrors the universal tree of life. These observations suggest synergistic selection during network evolution and provide insights into the hierarchical modularity of cellular networks.

原文English
頁(從 - 到)12820-12824
頁數5
期刊Proceedings of the National Academy of Sciences of the United States of America
100
發行號22
DOIs
出版狀態Published - 28 10月 2003

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