Evaluation of carotenoid extract from Dunaliella salina against cadmium-induced cytotoxicity and transforming growth factor β1 induced expression of smooth muscle α-actin with rat liver cell lines

Jau Tien Lin, Ying Chung Lee, Chao Chin Hu, You Cheng Shen, Fung Jou Lu, Deng Jye Yang*

*此作品的通信作者

研究成果: Article同行評審

18 引文 斯高帕斯(Scopus)

摘要

The carotenoid extract from Dunaliella salina was identified and quantitated. The effects against cadmium (Cd)-induced hepatotoxicity and transforming growth factor β1 (TGF-β1)-induced activation of hepatic stellate cells (HSCs) were evaluated. All-trans-β-carotene (474.82 mg/g extract) and 9- or 9′-cis-β-carotene (425.64 mg/g extract) were major carotenoids in the extract, accounting for 90.30% of total carotenoids (997.17 mg/g extract). Other carotenoids were all-trans-lutein (22.77 mg/g extract), all-trans-zeaxan-thin (39.26 mg/g extract), 13- or 13′-cis-β-carotene (17.18 mg/g extract), all-trans-α-carotene (9.26 mg/g extract) and 9- or 9′-cis-α-carotene (8.24 mg/g extract). The algal extract had a higher effect (p < 0.05) than all-trans-β-carotene in the reduction of cytotoxicity for CdCl2-treated Clone 9 cells and expression of smooth muscle α-actin (αSMA) for TGF-β1-treated HSC-T6 cells. These effects were shown to be concentration-dependent.

原文English
頁(從 - 到)301-306
頁數6
期刊Journal of Food and Drug Analysis
18
發行號5
出版狀態Published - 10月 2010

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