TY - JOUR
T1 - Evaluation of cardiac function by tissue Doppler echocardiography
T2 - Hemodynamic determinants and clinical application
AU - Yu, Wen Chung
AU - Lee, Wen Shin
AU - Huang, Wen Pin
AU - Wu, Chih Cheng
AU - Lin, Yao Ping
AU - Chen, Chen Huan
N1 - Funding Information:
This work was supported in part by the intramural grants from the Taipei Veterans General Hospital, Taiwan (grant no. VGH-90-250).
PY - 2005/1
Y1 - 2005/1
N2 - A total of 32 patients without regional wall motion abnormality of the left ventricle underwent sequential tissue Doppler echocardiography and cardiac catheterization. Peak velocities of systolic (Sa), early diastolic (Ea), and late diastolic (Aa) motion of the mitral annulus were measured. Normal references for Sa, Ea and Aa were obtained from 138 volunteers. Indices of left ventricular (LV) systolic and diastolic function were evaluated using high-fidelity LV pressure and volume signals. By multivariate analysis, Sa, Ea and As were significantly and independently related to the maximum of the first derivative of pressure over time (dP/dt max), LV relaxation time constant (τ), and LV ejection fraction (EF), respectively. Using the fifth percentiles of the age-stratified normal references as cut-offs, low Sa, low Ea and low Aa identified declined dP/dt max, prolonged τ and reduced EF, respectively, with good sensitivities and specificities. In conclusion, mitral annulus velocities by tissue Doppler echocardiography can be used to identify patients with declined dP/dt max, prolonged τ and reduced EF.
AB - A total of 32 patients without regional wall motion abnormality of the left ventricle underwent sequential tissue Doppler echocardiography and cardiac catheterization. Peak velocities of systolic (Sa), early diastolic (Ea), and late diastolic (Aa) motion of the mitral annulus were measured. Normal references for Sa, Ea and Aa were obtained from 138 volunteers. Indices of left ventricular (LV) systolic and diastolic function were evaluated using high-fidelity LV pressure and volume signals. By multivariate analysis, Sa, Ea and As were significantly and independently related to the maximum of the first derivative of pressure over time (dP/dt max), LV relaxation time constant (τ), and LV ejection fraction (EF), respectively. Using the fifth percentiles of the age-stratified normal references as cut-offs, low Sa, low Ea and low Aa identified declined dP/dt max, prolonged τ and reduced EF, respectively, with good sensitivities and specificities. In conclusion, mitral annulus velocities by tissue Doppler echocardiography can be used to identify patients with declined dP/dt max, prolonged τ and reduced EF.
KW - Diastolic function
KW - Hemodynamics
KW - Mitral annulus motion
KW - Systolic function
KW - Tissue Doppler imaging
UR - http://www.scopus.com/inward/record.url?scp=11844268015&partnerID=8YFLogxK
U2 - 10.1016/j.ultrasmedbio.2004.09.006
DO - 10.1016/j.ultrasmedbio.2004.09.006
M3 - Article
C2 - 15653227
AN - SCOPUS:11844268015
SN - 0301-5629
VL - 31
SP - 23
EP - 30
JO - Ultrasound in Medicine and Biology
JF - Ultrasound in Medicine and Biology
IS - 1
ER -