Estimating binding free energy of a putative growth factors EGF–VEGF complex – a computational bioanalytical study

Meng Han Lin, C. Allen Chang, Wolfgang B. Fischer*

*此作品的通信作者

研究成果: Article同行評審

4 引文 斯高帕斯(Scopus)

摘要

Epidermal growth factor (EGF) and homodimeric vascular endothelial growth factor (VEGF) bind to cell surface receptors. They are responsible for cell growth and angiogenesis, respectively. Docking of the individual proteins as monomeric units using ZDOCK 2.3.2 reveals a partial blocking of the receptor binding site of VEGF by EGF. The receptor binding site of EGF is not affected by VEGF. The calculated binding energy is found to be intermediate between the binding energies calculated for Alzheimer’s Aß42 and the barnase/barstar complex.

原文English
頁(從 - 到)1717-1724
頁數8
期刊Journal of Biomolecular Structure and Dynamics
34
發行號8
DOIs
出版狀態Published - 2 8月 2016

指紋

深入研究「Estimating binding free energy of a putative growth factors EGF–VEGF complex – a computational bioanalytical study」主題。共同形成了獨特的指紋。

引用此