摘要
Erinacines derived from Hericium erinaceus have been shown to possess various health benefits including neuroprotective effect against neurodegenerative diseases, yet the underlying mechanism remains unknown. Here we found that erinacine S enhances neurite outgrowth in a cell autonomous fashion. It promotes post-injury axon regeneration of PNS neurons and enhances regeneration on inhibitory substrates of CNS neurons. Using RNA-seq and bioinformatic analyses, erinacine S was found to cause the accumulation of neurosteroids in neurons. ELISA and neurosteroidogenesis inhibitor assays were performed to validate this effect. This research uncovers a previously unknown effect of erinacine S on raising the level of neurosteroids.
原文 | English |
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文章編號 | 3 |
頁(從 - 到) | 32-54 |
頁數 | 23 |
期刊 | Journal of Food and Drug Analysis |
卷 | 31 |
發行號 | 1 |
DOIs | |
出版狀態 | Published - 2023 |