Erinacine S from Hericium erinaceus mycelium promotes neuronal regeneration by inducing neurosteroids accumulation

Chun Yu Lin, Yi Ju Chen, Chih Hsuan Hsu, Yu Hsuan Lin, Peng Tzu Chen, Ting Han Kuo, Chris T. Ho, Hsin Hua Chen, Sih Jia Huang, Ho Chieh Chiu, Chin Chu Chen, Eric Hwang*

*此作品的通信作者

研究成果: Article同行評審

2 引文 斯高帕斯(Scopus)

摘要

Erinacines derived from Hericium erinaceus have been shown to possess various health benefits including neuroprotective effect against neurodegenerative diseases, yet the underlying mechanism remains unknown. Here we found that erinacine S enhances neurite outgrowth in a cell autonomous fashion. It promotes post-injury axon regeneration of PNS neurons and enhances regeneration on inhibitory substrates of CNS neurons. Using RNA-seq and bioinformatic analyses, erinacine S was found to cause the accumulation of neurosteroids in neurons. ELISA and neurosteroidogenesis inhibitor assays were performed to validate this effect. This research uncovers a previously unknown effect of erinacine S on raising the level of neurosteroids.

原文English
文章編號3
頁(從 - 到)32-54
頁數23
期刊Journal of Food and Drug Analysis
31
發行號1
DOIs
出版狀態Published - 2023

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