TY - JOUR
T1 - Epithelial-mesenchymal transition-related factors in solid tumor and hematological malignancy
AU - Chou, Yi Sheng
AU - Yang, Muh Hwa
N1 - Publisher Copyright:
© 2015.
PY - 2015/8/1
Y1 - 2015/8/1
N2 - The epithelial-mesenchymal transition (EMT) process plays pivotal roles in regulatory mechanisms of embryogenesis and wound healing physiologically, and organ fibrosis, cancer progression, and metastasis pathologically. EMT is classified as primary, secondary, and tertiary during embryonic development. EMT contributes to repair of tissue injury and fibrogenesis by re-epithelialization and regeneration of fibroblasts, respectively. The hallmarks of EMT include loss of contact inhibition, remodeling of extracellular matrix, and reorganization of cytoskeleton, along with expression of mesenchymal markers and reduction of epithelial markers. Cancer cells acquire stemness, migration and invasive capability, evade apoptosis, and initiate metastasis to distant organs. Several EMT regulators including Snail, Zeb1, Zeb2, and Twist in solid tumor and Sox4, distal-less homeobox gene 4 (. DLX4), Prdm14, Bmi1, and the forkhead box family in hematological malignancy are reviewed with regard to their signaling pathways, regulatory mechanisms, and clinical interactions.
AB - The epithelial-mesenchymal transition (EMT) process plays pivotal roles in regulatory mechanisms of embryogenesis and wound healing physiologically, and organ fibrosis, cancer progression, and metastasis pathologically. EMT is classified as primary, secondary, and tertiary during embryonic development. EMT contributes to repair of tissue injury and fibrogenesis by re-epithelialization and regeneration of fibroblasts, respectively. The hallmarks of EMT include loss of contact inhibition, remodeling of extracellular matrix, and reorganization of cytoskeleton, along with expression of mesenchymal markers and reduction of epithelial markers. Cancer cells acquire stemness, migration and invasive capability, evade apoptosis, and initiate metastasis to distant organs. Several EMT regulators including Snail, Zeb1, Zeb2, and Twist in solid tumor and Sox4, distal-less homeobox gene 4 (. DLX4), Prdm14, Bmi1, and the forkhead box family in hematological malignancy are reviewed with regard to their signaling pathways, regulatory mechanisms, and clinical interactions.
KW - Epithelial-mesenchymal transition
KW - Hematological malignancy
KW - Solid tumor
KW - Transcription factor
UR - http://www.scopus.com/inward/record.url?scp=84983200525&partnerID=8YFLogxK
U2 - 10.1016/j.jcma.2015.05.002
DO - 10.1016/j.jcma.2015.05.002
M3 - Review article
C2 - 26078096
AN - SCOPUS:84983200525
SN - 1726-4901
VL - 78
SP - 438
EP - 445
JO - Journal of the Chinese Medical Association
JF - Journal of the Chinese Medical Association
IS - 8
ER -