Epigenetic regulation of WNT3A enhancer during regeneration of injured cortical neurons

Chu Yuan Chang, Jui Hung Hung, Liang Wei Huang, Joye Li, Ka Shing Fung, Cheng Fu Kao, Linyi Chen*

*此作品的通信作者

研究成果: Article同行評審

摘要

Traumatic brain injury is known to reprogram the epigenome. Chromatin immunoprecipitation-sequencing of histone H3 lysine 27 acetylation (H3K27ac) and tri-methylation of histone H3 at lysine 4 (H3K4me3) marks was performed to address the transcriptional regulation of candidate regeneration-associated genes. In this study, we identify a novel enhancer region for induced WNT3A transcription during regeneration of injured cortical neurons. We further demonstrated an increased mono-methylation of histone H3 at lysine 4 (H3K4me1) modification at this enhancer concomitant with a topological interaction between sub-regions of this enhancer and with promoter of WNT3A gene. Together, this study reports a novel mechanism for WNT3A gene transcription and reveals a potential therapeutic intervention for neuronal regeneration.

原文English
文章編號1891
頁數16
期刊International journal of molecular sciences
21
發行號5
DOIs
出版狀態Published - 10 三月 2020

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