Entropic boundary effects on the elasticity of short DNA molecules

Yih Fan Chen*, David P. Wilson, Krishnan Raghunathan, Jens Christian Meiners

*此作品的通信作者

研究成果: Article同行評審

18 引文 斯高帕斯(Scopus)

摘要

We have measured the entropic elasticity of double-stranded-DNA molecules ranging from 247 to 1298 bp in length using axial force-clamp optical tweezers. We show that entropic end effects and excluded-volume forces from surface attachments become significant for such short molecules. The effective persistence length of the shortest molecules decreases by a factor of 2 compared to the established value for long molecules, and excluded-volume forces extend the molecules to about one third of their nominal contour length. We interpret these results in the framework of an inextensible semiflexible rod model.

原文English
文章編號020903
期刊Physical Review E - Statistical, Nonlinear, and Soft Matter Physics
80
發行號2
DOIs
出版狀態Published - 24 8月 2009

指紋

深入研究「Entropic boundary effects on the elasticity of short DNA molecules」主題。共同形成了獨特的指紋。

引用此