Enhanced Osteogenic Differentiation of Stem Cells on Phase-Engineered Graphene Oxide

Jia Wei Yang, Kuan Yu Hsieh, Priyank V. Kumar, Sheng Jen Cheng, You Rong Lin, Yu Chih Shen, Guan-Yu Chen*

*此作品的通信作者

研究成果: Article同行評審

20 引文 斯高帕斯(Scopus)

摘要

Graphene oxide (GO) has attracted significant interest as a template material for multiple applications due to its two-dimensional nature and established functionalization chemistries. However, for applications toward stem cell culture and differentiation, GO is often reduced to form reduced graphene oxide, resulting in a loss of oxygen content. Here, we induce a phase transformation in GO and demonstrate its benefits for enhanced stem cell culture and differentiation while conserving the oxygen content. The transformation results in the clustering of oxygen atoms on the GO surface, which greatly improves its ability toward substance adherence and results in enhanced differentiation of human mesenchymal stem cells toward the osteogenic lineage. Moreover, the conjugating ability of modified GO strengthened, which was examined by auxiliary osteogenic growth peptide conjugation. Overall, our work demonstrates GO's potential for stem cell applications while maintaining its oxygen content, which could enable further functionalization and fabrication of novel nano-biointerfaces.

原文English
頁(從 - 到)12497-12503
頁數7
期刊ACS Applied Materials and Interfaces
10
發行號15
DOIs
出版狀態Published - 18 四月 2018

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