Enhanced Cell Response to Zirconia Surface Immobilized with Type I Collagen

C. M. Hsu, Y. S. Sun, H. H. Huang*


研究成果: Article同行評審

11 引文 斯高帕斯(Scopus)


Zirconia (ZrO 2 ) dental implants provide good biocompatibility, have good corrosion resistance, and have a color that is similar to that of natural teeth. Unfortunately, ZrO 2 is a bioinert material and therefore achieves osseointegration difficultly. In this study, we sought to enhance osseointegration by producing rough ZrO 2 surfaces that contain hydroxyl groups (designated ZSA) through the use of sandblasting in conjunction with alkaline treatment. We immobilized type I collagen on ZSA surfaces using the natural cross-linker, procyanidin. Our results further showed that surfaces produced in ZSA-P/C featured more and steadier type I collagen than surfaces produced in ZSA-C. The ZSA-P/C also presented superior cell responses in terms of adhesion, proliferation, and mineralization of human bone marrow mesenchymal stem cells. The enhanced cell responses in the ZSA-P/C were induced through the prolonged activation of focal adhesion kinase, AKT (the phosphoinositide 3-kinase pathway), and p38 (the mitogen-activated protein kinase pathway). The simple and novel approach to immobilize type I collagen on roughened ZrO 2 surfaces presented in this article can likely benefit dental implant applications.

頁(從 - 到)556-563
期刊Journal of Dental Research
出版狀態Published - 1 5月 2019


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