En-face polarization-sensitive optical coherence tomography to characterize early-stage esophageal cancer and determine tumor margin

Ping Hsien Chen, Hiu Ki Lai, Yi Chen Yeh, Kuo Wei Chang, Ming Chih Hou, Wen Chuan Kuo*

*此作品的通信作者

研究成果: Article同行評審

1 引文 斯高帕斯(Scopus)

摘要

Current imaging tools are insufficiently sensitive to the early diagnosis of esophageal squamous cell carcinoma (ESCC). The application of polarization-sensitive optical coherence tomography (PS-OCT) to detect tumor-stroma interaction is an interesting issue in cancer diagnosis. In this translational study, we found that en-face PS-OCT effectively characterizes protruding, flat, and depressive type ESCC regardless of animal or human specimens. In addition, the tumor contour and margin could also be drawn and determined on a broad en-face view. The determined tumor margin could be in the proximity of 2 mm to the actual tumor margin, which was proved directly using histology.

原文English
頁(從 - 到)4773-4786
頁數14
期刊Biomedical Optics Express
13
發行號9
DOIs
出版狀態Published - 1 9月 2022

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