TY - JOUR
T1 - Emergence of OXA-48-producing hypervirulent Klebsiella pneumoniae strains in Taiwan
AU - Lin, Yi Tsung
AU - Chuang, Chien
AU - Chou, Sheng Hua
AU - Juan, Chih Han
AU - Yang, Tsuey Ching
AU - Kreiswirth, Barry N.
AU - Chen, Liang
N1 - Publisher Copyright:
© 2023, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2024/2
Y1 - 2024/2
N2 - The OXA-48-producing hypervirulent Klebsiella pneumoniae (hvKP) strains were rarely reported. In this study, we characterized three carbapenem-resistant hvKP strains (KP2185, NCRE61, and KP2683-1) isolated from renal abscess, scrotal abscess, and blood samples in a Taiwan hospital. The three strains belonged to two different clones: ST23 K1 (KP2683-1) and ST11 KL64 (KP2185 and NCRE61). KP2683-1 exhibited the highest virulence in an in vivo model. Whole-genome sequencing analysis showed that KP2185 and NCRE61 acquired IncFIB type plasmids containing a set of virulence genes (iroBCDN, iucABCD, rmpA, rmpA2, and iutA), while KP2683-1 acquired an IncL type plasmid harboring bla OXA-48.
AB - The OXA-48-producing hypervirulent Klebsiella pneumoniae (hvKP) strains were rarely reported. In this study, we characterized three carbapenem-resistant hvKP strains (KP2185, NCRE61, and KP2683-1) isolated from renal abscess, scrotal abscess, and blood samples in a Taiwan hospital. The three strains belonged to two different clones: ST23 K1 (KP2683-1) and ST11 KL64 (KP2185 and NCRE61). KP2683-1 exhibited the highest virulence in an in vivo model. Whole-genome sequencing analysis showed that KP2185 and NCRE61 acquired IncFIB type plasmids containing a set of virulence genes (iroBCDN, iucABCD, rmpA, rmpA2, and iutA), while KP2683-1 acquired an IncL type plasmid harboring bla OXA-48.
KW - Carbapenemase
KW - Hypervirulent strain
KW - OXA-48
UR - http://www.scopus.com/inward/record.url?scp=85178896623&partnerID=8YFLogxK
U2 - 10.1007/s10096-023-04733-3
DO - 10.1007/s10096-023-04733-3
M3 - Article
C2 - 38062176
AN - SCOPUS:85178896623
SN - 0934-9723
VL - 43
SP - 389
EP - 393
JO - European Journal of Clinical Microbiology and Infectious Diseases
JF - European Journal of Clinical Microbiology and Infectious Diseases
IS - 2
ER -