Emergence of OXA-48-producing hypervirulent Klebsiella pneumoniae strains in Taiwan

Yi Tsung Lin*, Chien Chuang, Sheng Hua Chou, Chih Han Juan, Tsuey Ching Yang, Barry N. Kreiswirth, Liang Chen*

*此作品的通信作者

研究成果: Article同行評審

摘要

The OXA-48-producing hypervirulent Klebsiella pneumoniae (hvKP) strains were rarely reported. In this study, we characterized three carbapenem-resistant hvKP strains (KP2185, NCRE61, and KP2683-1) isolated from renal abscess, scrotal abscess, and blood samples in a Taiwan hospital. The three strains belonged to two different clones: ST23 K1 (KP2683-1) and ST11 KL64 (KP2185 and NCRE61). KP2683-1 exhibited the highest virulence in an in vivo model. Whole-genome sequencing analysis showed that KP2185 and NCRE61 acquired IncFIB type plasmids containing a set of virulence genes (iroBCDN, iucABCD, rmpA, rmpA2, and iutA), while KP2683-1 acquired an IncL type plasmid harboring bla OXA-48.

原文English
頁(從 - 到)389-393
頁數5
期刊European Journal of Clinical Microbiology and Infectious Diseases
43
發行號2
DOIs
出版狀態Published - 2月 2024

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