Electrically responsive ZnO nanotubes for controlled release of biomolecules

C. C. Lin, Y. W. Chen, C. S. Hsiao, S. Y. Chen*

*此作品的通信作者

    研究成果: Article同行評審

    2 引文 斯高帕斯(Scopus)

    摘要

    We developed a novel electro-responsive drug delivery device by depositing fluorescein isothiocyanate (FITC)-loaded zinc oxide nanotubes (ZTs) onto indium tin oxide (ITO)/polyethylene terephthalate (PET) substrates (called FITC-ZTs-ITO/PET). With a large payload of FITC up to 0.98 mmol g−1, the FITC-ZTs simultaneously provide a burst-like FITC release and a repeated step-like release after application of an electrical field at specific resonant frequencies. Additionally, FITC-ZTs-ITO/PET is biocompatible with both HeLa and MRC5 cells for ZT concentrations below 50 μg/ml. These results demonstrate that FITC-ZTs-ITO/PET is a new platform that can provide local, on-demand electrically responsive drug release for biomedical applications.

    原文English
    頁(從 - 到)S802-S806
    期刊Ceramics International
    43
    DOIs
    出版狀態Published - 八月 2017

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