Electrical signal amplification of DNA hybridization by nanoparticles in a nanoscale gap

Chun Chi Chen*, Fu-Hsiang Ko, Chieh Tso Chen, Tzeng Feng Liu, Edward Yi Chang, Yuh-Shyong Yang, Su Jan Yan, Tieh Chi Chu

*此作品的通信作者

研究成果: Article同行評審

14 引文 斯高帕斯(Scopus)

摘要

We report two different methods to electrically sense deoxyribonucleic acid (DNA) hybridization and suggest that nanoparticles can act as hopping sites that amplify the conductance of the hybridized DNA strand. Single-stranded DNA has no amplification effect on conductance, but hybridized double-stranded DNA tethered to 10 nm gold nanoparticles exhibits a 30-fold amplification of conductance. As to the aldehyde-derived target DNA method, silver nanoparticles from silver ion reduction in the 70 nm nanogap enhance the conductance signal by 106.

原文English
文章編號253103
期刊Applied Physics Letters
91
發行號25
DOIs
出版狀態Published - 17 12月 2007

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