TY - JOUR
T1 - Effects of aging on neuromagnetic mismatch responses to pitch changes
AU - Cheng, Chia Hsiung
AU - Baillet, Sylvain
AU - Hsiao, Fu Jung
AU - Lin, Yung Yang
N1 - Funding Information:
The authors would like to thank Chih-Che Chou and Chou-Ming Cheng for technical assistance in MEG signal calibration and acquisition of MR images, as well as the participation of all the subjects and their families in this study. This work was supported by Taipei Veterans General Hospital ( V96ER3-004 , V97ER3-006 , VGHUST97-P6-24 , V98ER3-002 , V98S4-018 , V99ER3-006 , V101C-023 , V102C-101 , V102E9-003 ), National Science Council ( NSC-95-2314-B-010-030-MY3 , NSC-96-2628-B-010-030-MY3 , NSC-98-2321-B-010-007 , NSC-99-2321-B-010-004 , NSC-99-2628-B-010-011-MY3 , NSC-100-2321-B-010-004-MY3 , NSC-101-2917-I-010-003 , NSC-101-2314-B-010-068-MY3 ), and the Brain Research Center ( 102AC-B22 , 102AC-B7 ), National Yang-Ming University and a grant from Ministry of Education (Aim for the Top University Plan), Taipei, Taiwan .
PY - 2013/6/7
Y1 - 2013/6/7
N2 - Although aging-related alterations in the auditory sensory memory and involuntary change discrimination have been widely studied, it remains controversial whether the mismatch negativity (MMN) or its magnetic counterpart (MMNm) is modulated by physiological aging. This study aimed to examine the effects of aging on mismatch activity to pitch deviants by using a whole-head magnetoencephalography (MEG) together with distributed source modeling analysis. The neuromagnetic responses to oddball paradigms consisting of standards (1000 Hz, p=0.85) and deviants (1100. Hz, p= 0.15) were recorded in healthy young (n=20) and aged (n=18) male adults. We used minimum norm estimate of source reconstruction to characterize the spatiotemporal neural dynamics of MMNm responses. Distributed activations to MMNm were identified in the bilateral fronto-temporo-parietal areas. Compared to younger participants, the elderly exhibited a significant reduction of cortical activation in bilateral superior temporal guri, superior temporal sulci, inferior fontal gyri, orbitofrontal cortices and right inferior parietal lobules. In conclusion, our results suggest an aging-related decline in auditory sensory memory and automatic change detection as indexed by MMNm.
AB - Although aging-related alterations in the auditory sensory memory and involuntary change discrimination have been widely studied, it remains controversial whether the mismatch negativity (MMN) or its magnetic counterpart (MMNm) is modulated by physiological aging. This study aimed to examine the effects of aging on mismatch activity to pitch deviants by using a whole-head magnetoencephalography (MEG) together with distributed source modeling analysis. The neuromagnetic responses to oddball paradigms consisting of standards (1000 Hz, p=0.85) and deviants (1100. Hz, p= 0.15) were recorded in healthy young (n=20) and aged (n=18) male adults. We used minimum norm estimate of source reconstruction to characterize the spatiotemporal neural dynamics of MMNm responses. Distributed activations to MMNm were identified in the bilateral fronto-temporo-parietal areas. Compared to younger participants, the elderly exhibited a significant reduction of cortical activation in bilateral superior temporal guri, superior temporal sulci, inferior fontal gyri, orbitofrontal cortices and right inferior parietal lobules. In conclusion, our results suggest an aging-related decline in auditory sensory memory and automatic change detection as indexed by MMNm.
KW - Aging
KW - Auditory sensory memory
KW - Involuntary attention switch
KW - Magnetoencephalography (MEG)
KW - Mismatch negativity (MMN)
UR - http://www.scopus.com/inward/record.url?scp=84878414156&partnerID=8YFLogxK
U2 - 10.1016/j.neulet.2013.02.063
DO - 10.1016/j.neulet.2013.02.063
M3 - Article
C2 - 23562510
AN - SCOPUS:84878414156
SN - 0304-3940
VL - 544
SP - 20
EP - 24
JO - Neuroscience Letters
JF - Neuroscience Letters
ER -