Effective suppression of myocardial glucose uptake using predesigned low-carbohydrate boxed meals

Cheng Kai Huang, Po Nien Hou, Dmytro Luzhbin, Chao Wei Yang, Yu Ting Chang, Jay Wu*

*此作品的通信作者

研究成果: Article同行評審

摘要

Background: Dietary preparation protocols are an effective means to suppress physiological myocardial 18F-fluorodeoxyglucose (FDG) uptake. This study aimed to investigate the efficacy of various carbohydrate-restricted diets using predesigned boxed meals. Methods: The patients were divided into four groups to undergo different preparatory protocols as follows: a minimum 15-hours fast alone, two meals of high-fat, low-carbohydrate diet (HFLCD), two meals of high-animal-protein, low-carbohydrate diet (HAPLCD), and two meals of high-plant-based-protein, low-carbohydrate diet (HPPLCD). Boxed meals were prepared to meet the required carbohydrate restrictions. Myocardial SUVmax and SUVmean were measured and the suppression rate was analyzed. Results: The average myocardial SUVmax of fast alone, HFLCD, HAPLCD, and HPPLCD was 8.26 ± 5.85, 2.21 ± 1.50, 2.34 ± 1.88, and 4.10 ± 3.61, respectively, and the suppression rate was 36.6%, 93.3%, 93.3%, and 70%, respectively. The effectiveness of HFLCD, HAPLCD, and HPPLCD was all statistically superior to that of a 15-hours fast alone. SUVmax of HFLCD and HAPLCD showed no significant differences (p = 1), whereas HFLCD and HPPLCD had significant differences (p =.046). Conclusions: Using the predesigned boxed meals based on carbohydrate restriction, HFLCD, HAPLCD, and HPPLCD can be administered to patients with different dietary needs, while providing a substantial reduction in physiological myocardial FDG uptake.

原文English
期刊Journal of Nuclear Cardiology
DOIs
出版狀態Accepted/In press - 2022

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