Effect of different gold nanoparticle sizes to build an electrical detection DNA between nanogap electrodes

Tien Li Chang; Ya Wei Lee; Chun Chi Chen; Fu-Hsiang Ko

doi:10.1016/j.mee.2007.01.266

Effect of different gold nanoparticle sizes to build an electrical detection DNA between nanogap electrodes

Tien Li Chang^*, Ya Wei Lee, Chun Chi Chen, Fu-Hsiang Ko

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奈米科技碩博班

研究成果: Article › 同行評審

16 引文斯高帕斯（Scopus）

摘要

An experimental study for identifying DNA strands immobilized in the different particle sizes of gold nanoparticle (AuNP) between nanogap electrodes is presented. The nanogap-based electrics chip demonstrates a significant electrical property with a target DNA (TDNA) concentration of 10 pM in the different particle sizes of AuNP to be analyzed in order to make the assay useful for an integrated lab-on-a-chip application system. The biochips with nanogap electrodes are fabricated by e-beam lithography (EBL). Different from traditional detection methods including polymerase chain reaction (PCR) based on assays which are expensive and time consuming for DNA strands research. By the method of electrical characterization, a change in measured current through the different particle sizes of AuNP can pave the way for further use in sensitive biomolecule detection study.

原文	English
頁（從 - 到）	1698-1701
頁數	4
期刊	Microelectronic Engineering
卷	84
發行號	5-8
DOIs	https://doi.org/10.1016/j.mee.2007.01.266
出版狀態	Published - 5月 2007

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10.1016/j.mee.2007.01.266

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@article{85cc87b9aeb04f389cdb5bc35befb649,

title = "Effect of different gold nanoparticle sizes to build an electrical detection DNA between nanogap electrodes",

abstract = "An experimental study for identifying DNA strands immobilized in the different particle sizes of gold nanoparticle (AuNP) between nanogap electrodes is presented. The nanogap-based electrics chip demonstrates a significant electrical property with a target DNA (TDNA) concentration of 10 pM in the different particle sizes of AuNP to be analyzed in order to make the assay useful for an integrated lab-on-a-chip application system. The biochips with nanogap electrodes are fabricated by e-beam lithography (EBL). Different from traditional detection methods including polymerase chain reaction (PCR) based on assays which are expensive and time consuming for DNA strands research. By the method of electrical characterization, a change in measured current through the different particle sizes of AuNP can pave the way for further use in sensitive biomolecule detection study.",

keywords = "DNA chip, Electrical detection, Gold Nanoparticles, Particle size, Self-assembly",

author = "Chang, {Tien Li} and Lee, {Ya Wei} and Chen, {Chun Chi} and Fu-Hsiang Ko",

year = "2007",

month = may,

doi = "10.1016/j.mee.2007.01.266",

language = "English",

volume = "84",

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journal = "Microelectronic Engineering",

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AU - Chang, Tien Li

AU - Lee, Ya Wei

AU - Chen, Chun Chi

AU - Ko, Fu-Hsiang

PY - 2007/5

Y1 - 2007/5

N2 - An experimental study for identifying DNA strands immobilized in the different particle sizes of gold nanoparticle (AuNP) between nanogap electrodes is presented. The nanogap-based electrics chip demonstrates a significant electrical property with a target DNA (TDNA) concentration of 10 pM in the different particle sizes of AuNP to be analyzed in order to make the assay useful for an integrated lab-on-a-chip application system. The biochips with nanogap electrodes are fabricated by e-beam lithography (EBL). Different from traditional detection methods including polymerase chain reaction (PCR) based on assays which are expensive and time consuming for DNA strands research. By the method of electrical characterization, a change in measured current through the different particle sizes of AuNP can pave the way for further use in sensitive biomolecule detection study.

AB - An experimental study for identifying DNA strands immobilized in the different particle sizes of gold nanoparticle (AuNP) between nanogap electrodes is presented. The nanogap-based electrics chip demonstrates a significant electrical property with a target DNA (TDNA) concentration of 10 pM in the different particle sizes of AuNP to be analyzed in order to make the assay useful for an integrated lab-on-a-chip application system. The biochips with nanogap electrodes are fabricated by e-beam lithography (EBL). Different from traditional detection methods including polymerase chain reaction (PCR) based on assays which are expensive and time consuming for DNA strands research. By the method of electrical characterization, a change in measured current through the different particle sizes of AuNP can pave the way for further use in sensitive biomolecule detection study.

KW - DNA chip

KW - Electrical detection

KW - Gold Nanoparticles

KW - Particle size

KW - Self-assembly

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DO - 10.1016/j.mee.2007.01.266

M3 - Article

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SN - 0167-9317

VL - 84

SP - 1698

EP - 1701

JO - Microelectronic Engineering

JF - Microelectronic Engineering

IS - 5-8

ER -

Effect of different gold nanoparticle sizes to build an electrical detection DNA between nanogap electrodes

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