Effect of C-terminal residues of Aβ on copper binding affinity, structural conversion and aggregation

Shu Hsiang Huang, Shyue Chu Ke, Ta Hsin Lin, Hsin Bin Huang, Yi Cheng Chen

研究成果: Article同行評審

9 引文 斯高帕斯(Scopus)

摘要

Many properties of Aβ such as toxicity, aggregation and ROS formation are modulated by Cu2+. Previously, the coordination configuration and interaction of Cu2+ with the Aβ N-terminus has been extensively studied. However, the effect of Aβ C-terminal residues on related properties is still unclear. In the present study, several C-terminus-truncated Aβ peptides, including Aβ1-40, Aβ1-35, Aβ1-29, Aβ1-24 and Aβ1-16, were synthesized to characterize the effect of Aβ C-terminal residues on Cu2+ binding affinity, structure, aggregation ability and ROS formation. Results show that the Aβ C-terminal residues have effect on Cu2+ binding affinity, aggregation ability and inhibitory ability of ROS formation. Compared to the key residues responsible for Aβ aggregation and structure in the absence of Cu2+, it is more likely that residues 36-40, rather than residues 17-21 and 30-35, play a key role on the related properties of Aβ in the presence of Cu 2+.

原文English
文章編號e90385
期刊PLoS ONE
9
發行號3
DOIs
出版狀態Published - 3 3月 2014

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