Effect of a neuropilin-1-derived virus receptor trap on enterovirus a71 infection in vitro

Hsiang Ching Wang, Peng Nien Huang, Hui Chen Hung, Sung Nien Tseng, Chia Chia Chang, Ya Ru Tsai, Yun Ming Wang, Shin Ru Shih, John Tsu An Hsu*

*此作品的通信作者

研究成果: Article同行評審

2 引文 斯高帕斯(Scopus)

摘要

We discovered that neuropilin 1 (NRP1) is a new receptor candidate to mediate enterovirus A71 (EVA71) into cells. In the engineered form as a decoy receptor, NRP1 was able to recognize and neutralize EVA71 but not enterovirus D68 or coxsackievirus B3 (CVB3). NRP1 recognizes EVA71 through a novel domain on the VP3 capsid protein. The principle in the design, engineering, and refinement of the NRP1-based decoy receptor described in this study represents a general and well-suited antiviral strategy.

原文English
文章編號e00695-20
頁(從 - 到)1-8
頁數8
期刊Antimicrobial Agents and Chemotherapy
65
發行號1
DOIs
出版狀態Published - 1月 2021

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