Edge promoted ultrasensitive electrochemical detection of organic bio-molecules on epitaxial graphene nanowalls

Pradip Kumar Roy, Abhijit Ganguly, Wei Hsun Yang, Chien Ting Wu, Jih Shang Hwang, Yian Tai, Kuei Hsien Chen*, Li Chyong Chen, Surojit Chattopadhyay

*此作品的通信作者

研究成果: Article同行評審

34 引文 斯高帕斯(Scopus)

摘要

We report the simultaneous electrochemical detection of dopamine (DA), uric acid (UA) and ascorbic acid (AA) on three dimensional (3D) unmodified 'as-grown' epitaxial graphene nanowall arrays (EGNWs). The 3D few layer EGNWs, unlike the 2D planar graphene, offers an abundance of vertically oriented nano-graphitic-edges that exhibit fast electron-transfer kinetics and high electroactive surface area to geometrical area (EAA/GA≈134%), as evident from the Fe(CN)63-/4- redox kinetic study. The hexagonal sp2-C domains, on the basal plane of the EGNWs, facilitate efficient adsorption via spontaneous π-π interaction with the aromatic rings in DA and UA. Such affinity together with the fast electron kinetics enables simultaneous and unambiguous identification of individual AA, DA and UA from their mixture. The unique edge dominant EGNWs result in an unprecedented low limit of detection (experimental) of 0.033nM and highest sensitivity of 476.2μA/μM/cm2, for UA, which are orders of magnitude higher than comparable existing reports. A reaction kinetics based modeling of the edge-oriented 3D EGNW system is proposed to illustrate the superior electro-activity for bio-sensing applications.

原文English
頁(從 - 到)137-144
頁數8
期刊Biosensors and Bioelectronics
70
DOIs
出版狀態Published - 5 8月 2015

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