Edge promoted ultrasensitive electrochemical detection of organic bio-molecules on epitaxial graphene nanowalls

Pradip Kumar Roy; Abhijit Ganguly; Wei Hsun Yang; Chien Ting Wu; Jih Shang Hwang; Yian Tai; Kuei Hsien Chen; Li Chyong Chen; Surojit Chattopadhyay

doi:10.1016/j.bios.2015.03.027

Edge promoted ultrasensitive electrochemical detection of organic bio-molecules on epitaxial graphene nanowalls

Pradip Kumar Roy, Abhijit Ganguly, Wei Hsun Yang, Chien Ting Wu, Jih Shang Hwang, Yian Tai, Kuei Hsien Chen^*, Li Chyong Chen, Surojit Chattopadhyay

^*此作品的通信作者

生醫光電研究所

研究成果: Article › 同行評審

40 引文斯高帕斯（Scopus）

摘要

We report the simultaneous electrochemical detection of dopamine (DA), uric acid (UA) and ascorbic acid (AA) on three dimensional (3D) unmodified 'as-grown' epitaxial graphene nanowall arrays (EGNWs). The 3D few layer EGNWs, unlike the 2D planar graphene, offers an abundance of vertically oriented nano-graphitic-edges that exhibit fast electron-transfer kinetics and high electroactive surface area to geometrical area (EAA/GA≈134%), as evident from the Fe(CN)₆^3-/4- redox kinetic study. The hexagonal sp²-C domains, on the basal plane of the EGNWs, facilitate efficient adsorption via spontaneous π-π interaction with the aromatic rings in DA and UA. Such affinity together with the fast electron kinetics enables simultaneous and unambiguous identification of individual AA, DA and UA from their mixture. The unique edge dominant EGNWs result in an unprecedented low limit of detection (experimental) of 0.033nM and highest sensitivity of 476.2μA/μM/cm², for UA, which are orders of magnitude higher than comparable existing reports. A reaction kinetics based modeling of the edge-oriented 3D EGNW system is proposed to illustrate the superior electro-activity for bio-sensing applications.

原文	English
頁（從 - 到）	137-144
頁數	8
期刊	Biosensors and Bioelectronics
卷	70
DOIs	https://doi.org/10.1016/j.bios.2015.03.027
出版狀態	Published - 5 8月 2015

存取文件

10.1016/j.bios.2015.03.027

其它文件與鏈接

Link to publication in Scopus

引用此

@article{7c495922cd6645c7a4563936dbd71e94,

title = "Edge promoted ultrasensitive electrochemical detection of organic bio-molecules on epitaxial graphene nanowalls",

abstract = "We report the simultaneous electrochemical detection of dopamine (DA), uric acid (UA) and ascorbic acid (AA) on three dimensional (3D) unmodified 'as-grown' epitaxial graphene nanowall arrays (EGNWs). The 3D few layer EGNWs, unlike the 2D planar graphene, offers an abundance of vertically oriented nano-graphitic-edges that exhibit fast electron-transfer kinetics and high electroactive surface area to geometrical area (EAA/GA≈134%), as evident from the Fe(CN)63-/4- redox kinetic study. The hexagonal sp2-C domains, on the basal plane of the EGNWs, facilitate efficient adsorption via spontaneous π-π interaction with the aromatic rings in DA and UA. Such affinity together with the fast electron kinetics enables simultaneous and unambiguous identification of individual AA, DA and UA from their mixture. The unique edge dominant EGNWs result in an unprecedented low limit of detection (experimental) of 0.033nM and highest sensitivity of 476.2μA/μM/cm2, for UA, which are orders of magnitude higher than comparable existing reports. A reaction kinetics based modeling of the edge-oriented 3D EGNW system is proposed to illustrate the superior electro-activity for bio-sensing applications.",

keywords = "Dopamine, Electrochemical detection, Limit of detection, Reaction kinetics, Sensitivity, Three dimensional (3D) epitaxial graphene",

author = "{Kumar Roy}, Pradip and Abhijit Ganguly and Yang, {Wei Hsun} and Wu, {Chien Ting} and Hwang, {Jih Shang} and Yian Tai and Chen, {Kuei Hsien} and Chen, {Li Chyong} and Surojit Chattopadhyay",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier B.V.",

year = "2015",

month = aug,

day = "5",

doi = "10.1016/j.bios.2015.03.027",

language = "English",

volume = "70",

pages = "137--144",

journal = "Biosensors and Bioelectronics",

issn = "0956-5663",

publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Edge promoted ultrasensitive electrochemical detection of organic bio-molecules on epitaxial graphene nanowalls

AU - Kumar Roy, Pradip

AU - Ganguly, Abhijit

AU - Yang, Wei Hsun

AU - Wu, Chien Ting

AU - Hwang, Jih Shang

AU - Tai, Yian

AU - Chen, Kuei Hsien

AU - Chen, Li Chyong

AU - Chattopadhyay, Surojit

PY - 2015/8/5

Y1 - 2015/8/5

N2 - We report the simultaneous electrochemical detection of dopamine (DA), uric acid (UA) and ascorbic acid (AA) on three dimensional (3D) unmodified 'as-grown' epitaxial graphene nanowall arrays (EGNWs). The 3D few layer EGNWs, unlike the 2D planar graphene, offers an abundance of vertically oriented nano-graphitic-edges that exhibit fast electron-transfer kinetics and high electroactive surface area to geometrical area (EAA/GA≈134%), as evident from the Fe(CN)63-/4- redox kinetic study. The hexagonal sp2-C domains, on the basal plane of the EGNWs, facilitate efficient adsorption via spontaneous π-π interaction with the aromatic rings in DA and UA. Such affinity together with the fast electron kinetics enables simultaneous and unambiguous identification of individual AA, DA and UA from their mixture. The unique edge dominant EGNWs result in an unprecedented low limit of detection (experimental) of 0.033nM and highest sensitivity of 476.2μA/μM/cm2, for UA, which are orders of magnitude higher than comparable existing reports. A reaction kinetics based modeling of the edge-oriented 3D EGNW system is proposed to illustrate the superior electro-activity for bio-sensing applications.

AB - We report the simultaneous electrochemical detection of dopamine (DA), uric acid (UA) and ascorbic acid (AA) on three dimensional (3D) unmodified 'as-grown' epitaxial graphene nanowall arrays (EGNWs). The 3D few layer EGNWs, unlike the 2D planar graphene, offers an abundance of vertically oriented nano-graphitic-edges that exhibit fast electron-transfer kinetics and high electroactive surface area to geometrical area (EAA/GA≈134%), as evident from the Fe(CN)63-/4- redox kinetic study. The hexagonal sp2-C domains, on the basal plane of the EGNWs, facilitate efficient adsorption via spontaneous π-π interaction with the aromatic rings in DA and UA. Such affinity together with the fast electron kinetics enables simultaneous and unambiguous identification of individual AA, DA and UA from their mixture. The unique edge dominant EGNWs result in an unprecedented low limit of detection (experimental) of 0.033nM and highest sensitivity of 476.2μA/μM/cm2, for UA, which are orders of magnitude higher than comparable existing reports. A reaction kinetics based modeling of the edge-oriented 3D EGNW system is proposed to illustrate the superior electro-activity for bio-sensing applications.

KW - Dopamine

KW - Electrochemical detection

KW - Limit of detection

KW - Reaction kinetics

KW - Sensitivity

KW - Three dimensional (3D) epitaxial graphene

UR - http://www.scopus.com/inward/record.url?scp=84925339940&partnerID=8YFLogxK

U2 - 10.1016/j.bios.2015.03.027

DO - 10.1016/j.bios.2015.03.027

M3 - Article

C2 - 25801954

AN - SCOPUS:84925339940

SN - 0956-5663

VL - 70

SP - 137

EP - 144

JO - Biosensors and Bioelectronics

JF - Biosensors and Bioelectronics

ER -

Edge promoted ultrasensitive electrochemical detection of organic bio-molecules on epitaxial graphene nanowalls

摘要

存取文件

其它文件與鏈接

指紋

引用此