Early relapse in multiple sclerosis-associated optic neuritis following the use of interferon β-1a in Chinese patients

An Guor Wang, Yen Ching Lin, Shuu Jiun Wang, Ching Piao Tsai, May Yung Yen*

*此作品的通信作者

研究成果: Article同行評審

13 引文 斯高帕斯(Scopus)

摘要

Purpose: The incidence of multiple sclerosis (MS) is relatively rare in Chinese. The beneficial effect of interferon β-1a in modifying the disease course of MS has been rarely analyzed in Chinese patients. The aim of this study was to investigate the clinical response to interferon β1-a in Chinese patients with MS-associated optic neuritis (ON). Methods: A retrospective case control study was conducted in 20 MS patients with optic nerve involvement. The interferon (IF) group comprised ten patients receiving interferon β-1a. The noninterferon (NIF) group comprised another ten MS patients with optic nerve involvement who did not receive interferon treatment. The clinical characteristics, laboratory data, management, and disease course were retrospectively analyzed. The main outcomes of the study were the annualized relapse rate (ARR) for MS, and final visual outcome data. Results: The ARR did not differ between the pretreatment period and the posttreatment period within the IF group. There was also no significant decrease of ARR in the IF group when compared with the NIF group. However, we observed an early recurrence of ON in 50% of the IF cases following the use of interferon β-1a. The final visual outcome did not differ between the IF group and the NIF group. Conclusions: The use of interferon β-1a should be carefully monitored because early relapse of ON may complicate the treatment course in this patient group.

原文English
頁(從 - 到)537-542
頁數6
期刊Japanese Journal of Ophthalmology
50
發行號6
DOIs
出版狀態Published - 11月 2006

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