摘要
Purpose: The incidence of multiple sclerosis (MS) is relatively rare in Chinese. The beneficial effect of interferon β-1a in modifying the disease course of MS has been rarely analyzed in Chinese patients. The aim of this study was to investigate the clinical response to interferon β1-a in Chinese patients with MS-associated optic neuritis (ON). Methods: A retrospective case control study was conducted in 20 MS patients with optic nerve involvement. The interferon (IF) group comprised ten patients receiving interferon β-1a. The noninterferon (NIF) group comprised another ten MS patients with optic nerve involvement who did not receive interferon treatment. The clinical characteristics, laboratory data, management, and disease course were retrospectively analyzed. The main outcomes of the study were the annualized relapse rate (ARR) for MS, and final visual outcome data. Results: The ARR did not differ between the pretreatment period and the posttreatment period within the IF group. There was also no significant decrease of ARR in the IF group when compared with the NIF group. However, we observed an early recurrence of ON in 50% of the IF cases following the use of interferon β-1a. The final visual outcome did not differ between the IF group and the NIF group. Conclusions: The use of interferon β-1a should be carefully monitored because early relapse of ON may complicate the treatment course in this patient group.
原文 | English |
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頁(從 - 到) | 537-542 |
頁數 | 6 |
期刊 | Japanese Journal of Ophthalmology |
卷 | 50 |
發行號 | 6 |
DOIs | |
出版狀態 | Published - 11月 2006 |