Early detection of periodic sharp wave complexes on EEG by independent component analysis in patients with Creutzfeldt-Jakob disease

Po Shan Wang, Yu Te Wu, Chih I. Hung, Shan Yeong Kwan, Shin Teng, Bing Wen Soong*

*此作品的通信作者

研究成果: Article同行評審

29 引文 斯高帕斯(Scopus)

摘要

Sporadic Creutzfeldt-Jakob disease (sCJD) is the most common human prion disease. EEG is the method of choice to support the diagnosis of a human prion disease. Periodic sharp wave complexes (PSWCs) on the EEG usually indicate a progressive stage of CJD. However, PSWCs only become obvious at around 8 to 12 weeks after the onset of clinical symptoms, and in a few cases, even later. Independent component analysis (ICA) is a new technique to separate statistically independent components from a mixture of data. This study recruited seven patients who fit the criteria of CJD between 2002 and 2005 and 10 patients with Alzheimer's disease (AD) as control subjects. Using an ICA algorithm, we were able to split typical PSWCs into several independent temporal components in conjunction with spatial maps. The PSWCs were not observed in the initial EEG studies of patients with either AD or CJD. However, the ICA algorithm was able to extract periodic discharges and epileptiform discharges from raw EEG of patients with CJD at as early as 3 to 5 weeks after disease onset. Such discharges otherwise could hardly be discerned by visual inspection. In conclusion, ICA may increase the sensitivity of EEG and facilitate the early diagnosis of CJD.

原文English
頁(從 - 到)25-31
頁數7
期刊Journal of Clinical Neurophysiology
25
發行號1
DOIs
出版狀態Published - 2月 2008

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