Dual-Modality Bioluminescence and Ultrasound 3D 360-Degree Imaging System for Small Animal Tumor Imaging Using Homemade Transducers

Shih Po Su, Huihua Kenny Chiang*

*此作品的通信作者

研究成果: Conference contribution同行評審

摘要

The development of a dual-modality bioluminescence/ultrasound imaging system marks a significant advancement in preclinical research, particularly for creating accurate 3D tumor models. This system combines the long-term tumor tracking capabilities of bioluminescence imaging with the soft tissue examination strengths of ultrasound imaging. Its effectiveness in delineating tumor boundaries makes it an invaluable tool in oncology and related medical fields, enhancing our understanding of tissue structures and anomalies. The homemade 7.8 MHz ultrasound transducers were used to obtain structural images of nude mice, while an EMCCD camera captured functional bioluminescence images. This combination allowed for the reconstruction of 3D bioluminescence emissions, effectively integrating 3D bioluminescence tomography with 3D ultrasound. This dual-modality approach resulted in highly accurate tumor localization and morphology details, as indicated by a high DICE coefficient of 88.5% and minimal localization error of 0.4 mm. This demonstrates the system's capability in precise tumor mapping.

原文English
主出版物標題Medical Imaging 2024
主出版物子標題Ultrasonic Imaging and Tomography
編輯Christian Boehm, Nick Bottenus
發行者SPIE
ISBN(電子)9781510671683
DOIs
出版狀態Published - 2024
事件Medical Imaging 2024: Ultrasonic Imaging and Tomography - San Diego, 美國
持續時間: 19 2月 202420 2月 2024

出版系列

名字Progress in Biomedical Optics and Imaging - Proceedings of SPIE
12932
ISSN(列印)1605-7422

Conference

ConferenceMedical Imaging 2024: Ultrasonic Imaging and Tomography
國家/地區美國
城市San Diego
期間19/02/2420/02/24

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