TY - GEN
T1 - Dual-Modality Bioluminescence and Ultrasound 3D 360-Degree Imaging System for Small Animal Tumor Imaging Using Homemade Transducers
AU - Su, Shih Po
AU - Chiang, Huihua Kenny
N1 - Publisher Copyright:
© 2024 SPIE.
PY - 2024
Y1 - 2024
N2 - The development of a dual-modality bioluminescence/ultrasound imaging system marks a significant advancement in preclinical research, particularly for creating accurate 3D tumor models. This system combines the long-term tumor tracking capabilities of bioluminescence imaging with the soft tissue examination strengths of ultrasound imaging. Its effectiveness in delineating tumor boundaries makes it an invaluable tool in oncology and related medical fields, enhancing our understanding of tissue structures and anomalies. The homemade 7.8 MHz ultrasound transducers were used to obtain structural images of nude mice, while an EMCCD camera captured functional bioluminescence images. This combination allowed for the reconstruction of 3D bioluminescence emissions, effectively integrating 3D bioluminescence tomography with 3D ultrasound. This dual-modality approach resulted in highly accurate tumor localization and morphology details, as indicated by a high DICE coefficient of 88.5% and minimal localization error of 0.4 mm. This demonstrates the system's capability in precise tumor mapping.
AB - The development of a dual-modality bioluminescence/ultrasound imaging system marks a significant advancement in preclinical research, particularly for creating accurate 3D tumor models. This system combines the long-term tumor tracking capabilities of bioluminescence imaging with the soft tissue examination strengths of ultrasound imaging. Its effectiveness in delineating tumor boundaries makes it an invaluable tool in oncology and related medical fields, enhancing our understanding of tissue structures and anomalies. The homemade 7.8 MHz ultrasound transducers were used to obtain structural images of nude mice, while an EMCCD camera captured functional bioluminescence images. This combination allowed for the reconstruction of 3D bioluminescence emissions, effectively integrating 3D bioluminescence tomography with 3D ultrasound. This dual-modality approach resulted in highly accurate tumor localization and morphology details, as indicated by a high DICE coefficient of 88.5% and minimal localization error of 0.4 mm. This demonstrates the system's capability in precise tumor mapping.
KW - Bioluminescence imaging
KW - Dual-modality imaging system
KW - Homemade ultrasound transducers
KW - In vivo
KW - Ultrasound tomography
UR - http://www.scopus.com/inward/record.url?scp=85193522220&partnerID=8YFLogxK
U2 - 10.1117/12.3009797
DO - 10.1117/12.3009797
M3 - Conference contribution
AN - SCOPUS:85193522220
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Medical Imaging 2024
A2 - Boehm, Christian
A2 - Bottenus, Nick
PB - SPIE
T2 - Medical Imaging 2024: Ultrasonic Imaging and Tomography
Y2 - 19 February 2024 through 20 February 2024
ER -