Droplet Size-Aware High-Level Synthesis for Micro-Electrode-Dot-Array Digital Microfluidic Biochips

Zipeng Li, Kelvin Yi Tse Lai, Po Hsien Yu, Krishnendu Chakrabarty, Tsung Yi Ho, Chen-Yi Lee

研究成果: Article同行評審

28 引文 斯高帕斯(Scopus)

摘要

A digital microfluidic biochip (DMFB) is an attractive technology platform for automating laboratory procedures in biochemistry. In recent years, DMFBs based on a microelectrode-dot-array (MEDA) architecture have been demonstrated. However, due to the inherent differences between today's DMFBs and MEDA, existing synthesis solutions for biochemistry mapping cannot be utilized for MEDA biochips. We present the first synthesis approach that can be used for MEDA biochips. We first present a general analytical model for droplet velocity and validate it experimentally using a fabricated MEDA biochip. We then present the proposed synthesis method targeting reservoir placement, operation scheduling, module placement, routing of droplets of various sizes, and diagonal movement of droplets in a two-dimensional array. Simulation results using benchmarks and experimental results using a fabricated MEDA biochip demonstrate the effectiveness of the proposed synthesis technique.

原文English
文章編號7883927
頁(從 - 到)612-626
頁數15
期刊IEEE Transactions on Biomedical Circuits and Systems
11
發行號3
DOIs
出版狀態Published - 1 六月 2017

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