摘要
Diversity-oriented synthesis of novel benzimidazole linked indolo-benzodiazepine/quinoxaline ring systems using poly(ethylene glycol) as soluble polymer support is described. Commercially available 4-fluoro-3-nitrobenzoic acid and indoline were utilized for the construction of these annulated biheterocyclic compound libraries having multiple privileged structures with three-point structural diversity. A reagent based diversification approach coupled with the Pictet-Spengler-type condensation was used to construct the tetracyclic indolo-benzodiazepines/quinoxalines on substituted benzimidazoles.
| 原文 | English |
|---|---|
| 頁（從 - 到） | 391-398 |
| 頁數 | 8 |
| 期刊 | ACS Combinatorial Science |
| 卷 | 13 |
| 發行號 | 4 |
| DOIs | |
| 出版狀態 | Published - 11 7月 2011 |