Divergent ionic liquid supported synthesis of isolable guanidine linked quinoxalinone and benzodiamine

Li Hsun Chen, Zhan Hui Xu, Chun Chung Lin, Chung-Ming Sun*

*此作品的通信作者

研究成果: Article同行評審

3 引文 斯高帕斯(Scopus)

摘要

Ionic liquid supported synthesis of guanidine linked piperazine, diazepane, and aminomethylpiperidine to difluoroquinoxalinones and difluoro benzodiamine was achieved by two regioisomeric products. They were isolated from one pot reduction and intramolecular cyclization to afford quinoxalinone ring system with traceless cleavage of ionic liquid support. Besides, the ionic-supported other isomer was further cleaved in methanol. All the reactions were carried out on an ionic liquid support under various conditions to deliver biologically relevant scaffolds with high purity and excellent yields.

原文English
頁(從 - 到)454-458
頁數5
期刊Tetrahedron Letters
54
發行號6
DOIs
出版狀態Published - 6 二月 2013

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