Divergent ionic liquid supported synthesis of isolable guanidine linked quinoxalinone and benzodiamine

Li Hsun Chen; Zhan Hui Xu; Chun Chung Lin; Chung-Ming Sun

doi:10.1016/j.tetlet.2012.11.012

Divergent ionic liquid supported synthesis of isolable guanidine linked quinoxalinone and benzodiamine

Li Hsun Chen, Zhan Hui Xu, Chun Chung Lin, Chung-Ming Sun^*

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摘要

Ionic liquid supported synthesis of guanidine linked piperazine, diazepane, and aminomethylpiperidine to difluoroquinoxalinones and difluoro benzodiamine was achieved by two regioisomeric products. They were isolated from one pot reduction and intramolecular cyclization to afford quinoxalinone ring system with traceless cleavage of ionic liquid support. Besides, the ionic-supported other isomer was further cleaved in methanol. All the reactions were carried out on an ionic liquid support under various conditions to deliver biologically relevant scaffolds with high purity and excellent yields.

原文	English
頁（從 - 到）	454-458
頁數	5
期刊	Tetrahedron Letters
卷	54
發行號	6
DOIs	https://doi.org/10.1016/j.tetlet.2012.11.012
出版狀態	Published - 6 2月 2013

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10.1016/j.tetlet.2012.11.012

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abstract = "Ionic liquid supported synthesis of guanidine linked piperazine, diazepane, and aminomethylpiperidine to difluoroquinoxalinones and difluoro benzodiamine was achieved by two regioisomeric products. They were isolated from one pot reduction and intramolecular cyclization to afford quinoxalinone ring system with traceless cleavage of ionic liquid support. Besides, the ionic-supported other isomer was further cleaved in methanol. All the reactions were carried out on an ionic liquid support under various conditions to deliver biologically relevant scaffolds with high purity and excellent yields.",

keywords = "Ionic liquid support, Microwave synthesis, One-Bead-Two-Compound, Quinoxalinones",

author = "Chen, {Li Hsun} and Xu, {Zhan Hui} and Lin, {Chun Chung} and Chung-Ming Sun",

year = "2013",

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doi = "10.1016/j.tetlet.2012.11.012",

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T1 - Divergent ionic liquid supported synthesis of isolable guanidine linked quinoxalinone and benzodiamine

AU - Chen, Li Hsun

AU - Xu, Zhan Hui

AU - Lin, Chun Chung

AU - Sun, Chung-Ming

PY - 2013/2/6

Y1 - 2013/2/6

N2 - Ionic liquid supported synthesis of guanidine linked piperazine, diazepane, and aminomethylpiperidine to difluoroquinoxalinones and difluoro benzodiamine was achieved by two regioisomeric products. They were isolated from one pot reduction and intramolecular cyclization to afford quinoxalinone ring system with traceless cleavage of ionic liquid support. Besides, the ionic-supported other isomer was further cleaved in methanol. All the reactions were carried out on an ionic liquid support under various conditions to deliver biologically relevant scaffolds with high purity and excellent yields.

AB - Ionic liquid supported synthesis of guanidine linked piperazine, diazepane, and aminomethylpiperidine to difluoroquinoxalinones and difluoro benzodiamine was achieved by two regioisomeric products. They were isolated from one pot reduction and intramolecular cyclization to afford quinoxalinone ring system with traceless cleavage of ionic liquid support. Besides, the ionic-supported other isomer was further cleaved in methanol. All the reactions were carried out on an ionic liquid support under various conditions to deliver biologically relevant scaffolds with high purity and excellent yields.

KW - Ionic liquid support

KW - Microwave synthesis

KW - One-Bead-Two-Compound

KW - Quinoxalinones

UR - http://www.scopus.com/inward/record.url?scp=84872016699&partnerID=8YFLogxK

U2 - 10.1016/j.tetlet.2012.11.012

DO - 10.1016/j.tetlet.2012.11.012

M3 - Article

AN - SCOPUS:84872016699

SN - 0040-4039

VL - 54

SP - 454

EP - 458

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 6

ER -

Divergent ionic liquid supported synthesis of isolable guanidine linked quinoxalinone and benzodiamine

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