Disrupted thalamo-cortical connectivity in schizophrenia: A morphometric correlation analysis

Yuanchao Zhang, Tung Ping Su, Bing Liu, Yuan Zhou, Kun Hsien Chou, Chun Yi Lo, Chia Chun Hung, Wei Ling Chen, Tianzi Jiang*, Ching Po Lin


研究成果: Article同行評審

15 引文 斯高帕斯(Scopus)


Increasing studies have implicated the thalamus in schizophrenia, supporting the view that this structure has an important role in this disorder. Given that extensive reciprocal connections exist between the thalamus and the cerebral cortex, it is believed that disruptions of the thalamo-cortical connections may underlie the multiplicity of schizophrenic symptoms. Therefore, assessing the relationship between the thalamus and the neocortex may provide new insights into the pathophysiology of schizophrenia. We analyzed magnetic resonance images from a sample of 101 schizophrenic patients and 101 healthy controls. By assessing the correlation between the thalamic volume and cortical thickness at each vertex on the cortical surface, a thalamo-cortical network was obtained for each group. We compared the patterns of thalamo-cortical connectivity between the two groups. Compared with healthy controls, less distributed cortical regions were identified in the thalamo-cortical network in patients with schizophrenia. Vertex-wise comparison revealed decreased thalamo-cortical connectivity in bilateral inferior frontal gyrus, the left superior temporal gyrus and the right parieto-occipital region in schizophrenia. The observed disruptions in thalamo-cortical connectivity might be the substrate underlying the wide range of schizophrenic symptoms and provide further evidence to support the notion of schizophrenia as a disorder of brain dysconnectivity.

頁(從 - 到)129-135
期刊Schizophrenia Research
出版狀態Published - 3月 2014


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