Dispersion of Heterogeneous Medium in Pulsatile Blood Flow and Absolute Pulsatile Flow Velocity Quantification

Ko Kung Chen, Chung Jung Lin, Wei Fa Chu

研究成果: Article同行評審

1 引文 斯高帕斯(Scopus)


Heterogeneous medium enhanced angiograms are key diagnostic tools in clinical practice; the associated hemodynamic information is crucial for diagnosing cardiovascular diseases. However, the dynamics of such medium in physiological blood flow are poorly understood. Herein, we report a previously unnoticed dispersion pattern, which is a universal phenomenon, of a medium in pulsatile blood flow. We present a physical theory for studying the dispersion of a steadily injected heterogeneous medium into a thin tubular blood vessel in which the blood flow is pulsatile. In a thin tubular blood vessel, we demonstrate that variations of concentration associated with the heterogeneous medium obey a one-dimensional advection diffusion equation, and the diffusion has limited effect whenever a short vascular segment is considered. A distinct feature of the distribution of the medium in the axial distance–time plane is a “dilation-retraction” pattern. The time evolution signals at different axial positions exhibit distinct concentration waveforms. A numerical scheme is proposed for exploiting this information to estimate the pulsatile velocity. Artificial data are adopted to validate the scheme. Real X-ray angiography is also analyzed to support our theory and method. The theory is applicable whenever imaging protocols involve a heterogeneous medium in pulsatile flow.

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期刊IEEE Transactions on Medical Imaging
出版狀態Accepted/In press - 2022


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