Discovery of new dibenzodiazepine derivatives as antibacterials against intracellular bacteria

Ling Han Chen, Man Yi Lin, Hsueh Chun Lin, Fan Wei Yang, Hsiao Wei Liao, Chung Wai Shiau, Hao Chieh Chiu*, Jung Chen Su*

*此作品的通信作者

研究成果: Article同行評審

摘要

The emergence and spread of multidrug-resistant bacteria underscore the critical need for novel antibacterial interventions. In our screening of 12 synthesized thienobenzodiazepines, pyridobenzodiazepines, and dibenzodiazepines, we successfully identified a small molecule compound SW33. Notably, SW33 demonstrated potent inhibitory activity against intracellular multidrug-resistant and fluoroquinolone-resistant strains of S. typhimurium in both macrophages and epithelial cells. Furthermore, SW33 was also effective against intramacrophagic Salmonella typhi, Yersinia enterocolitica, and Listeria monocytogenes. These significant findings suggest that SW33 possesses broad-spectrum activity against intracellular bacteria.

原文English
頁(從 - 到)283-292
頁數10
期刊RSC Medicinal Chemistry
15
發行號1
DOIs
出版狀態Published - 11 12月 2023

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