Discovery of antipsychotic loxapine derivatives against intracellular multidrug-resistant bacteria

Hsueh Chun Lin, Yi Lun Wu, Cheng Yun Hsu, Man Yi Lin, Ling Han Chen, Chung Wai Shiau*, Hao Chieh Chiu*

*此作品的通信作者

研究成果: Article同行評審

4 引文 斯高帕斯(Scopus)

摘要

The emergence and spread of multidrug-resistant bacteria highlight the need for new antibacterial interventions. A screening of 24 newly synthesized dibenzoxazepines identified a small molecule compound, SW14, with potent inhibitory activity against intracellular multidrug-resistant and fluoroquinolone-resistant strains of S. typhimurium in macrophages and epithelial cells. Moreover, intra-macrophagic Salmonella typhi, Yersinia enterocolitica, and Listeria monocytogenes and methicillin-resistant Staphylococcus aureus are also susceptible to SW14. Overall, our findings suggest that SW14 has a broad-spectrum activity against intracellular bacteria.

原文English
頁(從 - 到)1361-1366
頁數6
期刊RSC Medicinal Chemistry
13
發行號11
DOIs
出版狀態Published - 11 8月 2022

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