Directly thiolated modification onto the surface of detonation nanodiamonds

Ming Hua Hsu; Hong Chuang; Fong Yu Cheng; Ying Pei Huang; Chien Chung Han; Jiun Yu Chen; Su Chin Huang; Jen Kun Chen; Dian Syue Wu; Hsueh Liang Chu; Chia-Ching Chang

doi:10.1021/am500324z

Directly thiolated modification onto the surface of detonation nanodiamonds

Ming Hua Hsu^*, Hong Chuang, Fong Yu Cheng, Ying Pei Huang, Chien Chung Han, Jiun Yu Chen, Su Chin Huang, Jen Kun Chen, Dian Syue Wu, Hsueh Liang Chu, Chia-Ching Chang

^*此作品的通信作者

生物科技學系

研究成果: Article › 同行評審

35 引文斯高帕斯（Scopus）

摘要

An efficient method for modifying the surface of detonation nanodiamonds (5 and 100 nm) with thiol groups (-SH) by using an organic chemistry strategy is presented herein. Thiolated nanodiamonds were characterized by spectroscopic techniques, and the atomic percentage of sulfur was analyzed by elemental analysis and X-ray photoelectron spectroscopy. The conjugation between thiolated nanodiamonds and gold nanoparticles was elucidated by transmission electron microscopy and UV-vis spectrometry. Moreover, the material did not show significant cytotoxicity to the human lung carcinoma cell line and may prospectively be applied in bioconjugated technology. The new method that we elucidated may significantly improve the approach to surface modification of detonation nanodiamonds and build up a new platform for the application of nanodiamonds.

原文	English
頁（從 - 到）	7198-7203
頁數	6
期刊	ACS Applied Materials and Interfaces
卷	6
發行號	10
DOIs	https://doi.org/10.1021/am500324z
出版狀態	Published - 28 5月 2014

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10.1021/am500324z

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@article{615336f4539843739ad7746eeab4f2da,

title = "Directly thiolated modification onto the surface of detonation nanodiamonds",

abstract = "An efficient method for modifying the surface of detonation nanodiamonds (5 and 100 nm) with thiol groups (-SH) by using an organic chemistry strategy is presented herein. Thiolated nanodiamonds were characterized by spectroscopic techniques, and the atomic percentage of sulfur was analyzed by elemental analysis and X-ray photoelectron spectroscopy. The conjugation between thiolated nanodiamonds and gold nanoparticles was elucidated by transmission electron microscopy and UV-vis spectrometry. Moreover, the material did not show significant cytotoxicity to the human lung carcinoma cell line and may prospectively be applied in bioconjugated technology. The new method that we elucidated may significantly improve the approach to surface modification of detonation nanodiamonds and build up a new platform for the application of nanodiamonds.",

keywords = "detonation nanodiamond, functionalized nanodiamond, nanodiamond, surface modification, thiolated, thiolated nanodiamond",

author = "Hsu, {Ming Hua} and Hong Chuang and Cheng, {Fong Yu} and Huang, {Ying Pei} and Han, {Chien Chung} and Chen, {Jiun Yu} and Huang, {Su Chin} and Chen, {Jen Kun} and Wu, {Dian Syue} and Chu, {Hsueh Liang} and Chia-Ching Chang",

year = "2014",

month = may,

day = "28",

doi = "10.1021/am500324z",

language = "English",

volume = "6",

pages = "7198--7203",

journal = "ACS Applied Materials and Interfaces",

issn = "1944-8244",

publisher = "American Chemical Society",

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TY - JOUR

T1 - Directly thiolated modification onto the surface of detonation nanodiamonds

AU - Hsu, Ming Hua

AU - Chuang, Hong

AU - Cheng, Fong Yu

AU - Huang, Ying Pei

AU - Han, Chien Chung

AU - Chen, Jiun Yu

AU - Huang, Su Chin

AU - Chen, Jen Kun

AU - Wu, Dian Syue

AU - Chu, Hsueh Liang

AU - Chang, Chia-Ching

PY - 2014/5/28

Y1 - 2014/5/28

N2 - An efficient method for modifying the surface of detonation nanodiamonds (5 and 100 nm) with thiol groups (-SH) by using an organic chemistry strategy is presented herein. Thiolated nanodiamonds were characterized by spectroscopic techniques, and the atomic percentage of sulfur was analyzed by elemental analysis and X-ray photoelectron spectroscopy. The conjugation between thiolated nanodiamonds and gold nanoparticles was elucidated by transmission electron microscopy and UV-vis spectrometry. Moreover, the material did not show significant cytotoxicity to the human lung carcinoma cell line and may prospectively be applied in bioconjugated technology. The new method that we elucidated may significantly improve the approach to surface modification of detonation nanodiamonds and build up a new platform for the application of nanodiamonds.

AB - An efficient method for modifying the surface of detonation nanodiamonds (5 and 100 nm) with thiol groups (-SH) by using an organic chemistry strategy is presented herein. Thiolated nanodiamonds were characterized by spectroscopic techniques, and the atomic percentage of sulfur was analyzed by elemental analysis and X-ray photoelectron spectroscopy. The conjugation between thiolated nanodiamonds and gold nanoparticles was elucidated by transmission electron microscopy and UV-vis spectrometry. Moreover, the material did not show significant cytotoxicity to the human lung carcinoma cell line and may prospectively be applied in bioconjugated technology. The new method that we elucidated may significantly improve the approach to surface modification of detonation nanodiamonds and build up a new platform for the application of nanodiamonds.

KW - detonation nanodiamond

KW - functionalized nanodiamond

KW - nanodiamond

KW - surface modification

KW - thiolated

KW - thiolated nanodiamond

UR - http://www.scopus.com/inward/record.url?scp=84901650471&partnerID=8YFLogxK

U2 - 10.1021/am500324z

DO - 10.1021/am500324z

M3 - Article

C2 - 24766528

AN - SCOPUS:84901650471

SN - 1944-8244

VL - 6

SP - 7198

EP - 7203

JO - ACS Applied Materials and Interfaces

JF - ACS Applied Materials and Interfaces

IS - 10

ER -

Directly thiolated modification onto the surface of detonation nanodiamonds

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