Direct and in vitro observation of growth hormone receptor molecules in A549 human lung epithelial cells by nanodiamond labeling

C. Y. Cheng*, E. Perevedentseva, J. S. Tu, P. H. Chung, C. L. Cheng, K. K. Liu, Jui-I Chao, P. H. Chen, Chia-Ching Chang

*此作品的通信作者

研究成果: Article同行評審

124 引文 斯高帕斯(Scopus)

摘要

This letter presents direct observation of growth hormone receptor in one single cancer cell using nanodiamond-growth hormone complex as a specific probe. The interaction of surface growth hormone receptor of A549 human lung epithelial cells with growth hormone was observed using nanodiamond's unique spectroscopic signal via confocal Raman mapping. The growth hormone molecules were covalent conjugated to 100 nm diameter carboxylated nanodiamonds, which can be recognized specifically by the growth hormone receptors of A549 cell. The Raman spectroscopic signal of diamond provides direct and in vitro observation of growth hormone receptors in physiology condition in a single cell level.

原文English
文章編號163903
期刊Applied Physics Letters
90
發行號16
DOIs
出版狀態Published - 16 4月 2007

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