Diffusion MRI predicts transrectal ultrasound biopsy results in prostate cancer detection

Yu Jen Chen, Yeong Shiau Pu, Shih Chieh Chueh, Chia Tung Shun, Woei Chyn Chu, Wen Yih Isaac Tseng

研究成果: Article同行評審

11 引文 斯高帕斯(Scopus)


Purpose To evaluate the ability of diffusion tensor imaging (DTI) to predict the transrectal ultrasound (TRUS) biopsy outcomes in persons who have no history of previous TRUS biopsy and present with elevated prostate-specific antigen (PSA) levels. Materials and Methods Thirty-seven participants underwent DTI, followed by 12-core TRUS-guided needle biopsy within 2 weeks. DTI was performed using endorectal coils on a 1.5 Tesla scanner at 1-mm3 spatial resolution. By comparing with the TRUS biopsy results, the optimum thresholds of the trace apparent diffusion coefficient (tADC) and of the nodular size were investigated. The diagnostic performance of both criteria, the tADC threshold (Criteria A) and the tADC threshold combined with nodular size threshold (Criteria B), were evaluated. Results The optimum tADC threshold was 1.0 μm2/ms. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of prostate cancer (PCA) detection for Criteria A were 98%, 89%, 73%, 99%, and 91%, respectively, and were 97%, 98%, 92%, 99% and 98% for Criteria B. Conclusion Owing to high negative predictive value, the tADC threshold could be used to exclude subjects with clinically undetectable PCA. Adding the nodular size threshold, the combined threshold could identify the tADC-positive segments that are likely to yield positive biopsy results.

頁(從 - 到)356-363
期刊Journal of Magnetic Resonance Imaging
出版狀態Published - 2月 2011


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