Differential network biology reveals a positive correlation between a novel protein-protein interaction and cancer cells migration

Chia Hung Liu, Tzu Chi Chen, Chun Houh Chen, Cheng Yan Kao, Chi Ying F. Huang*

*此作品的通信作者

研究成果: Conference contribution同行評審

3 引文 斯高帕斯(Scopus)

摘要

This paper introduces a differential network biology for discovering tumor migration. We applied statistical methods to prioritize PPI candidates and an in situ proximity ligation assay to verify 67 endogenous PPIs among 21 interlinked pathways in two hepatocellular carcinoma (HCC) cells, Huh7 (minimally migratory cells) and Mahlavu (highly migratory cells). Differential network biology analysis was applied to determine the novel interaction, CRKL-FLT1, has a high centrality ranking, and the expression of this interaction is strongly correlated with the migratory ability of HCC and other cancer cell lines. Knockdown of CRKL and FLT1 in HCC cells leads to a decrease in cell migration. This study demonstrated that functional exploration of a disease network with differential network in interlinked pathways via PPIs can be used to discover tumor migration.

原文English
主出版物標題2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013
頁面2700-2703
頁數4
DOIs
出版狀態Published - 2013
事件2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013 - Osaka, Japan
持續時間: 3 7月 20137 7月 2013

出版系列

名字Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ISSN(列印)1557-170X

Conference

Conference2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013
國家/地區Japan
城市Osaka
期間3/07/137/07/13

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