Differential mechanisms of synaptic plasticity for susceptibility and resilience to chronic social defeat stress in male mice

Chi Wei Lee, Yen Po Fang, Ming Chia Chu, Yueh Jung Chung, Hsiang Chi, Chih Wei Tang, Edmund Cheung So, Hsin Chuan Lin, Hui Ching Lin*

*此作品的通信作者

研究成果: Article同行評審

5 引文 斯高帕斯(Scopus)

摘要

Mood dysregulation refers to the inability of a person to control their negative emotions, and it is linked to various stressful experiences. Dysregulated neural synaptic plasticity and actin-filament dynamics are important regulators of stress response in animal models. However, until now, there is no evidence to differential the mechanisms of synaptic plasticity and actin-filament dynamics in stress susceptibility and stress-resistant. Here we found that depression-like behaviour was observed in the susceptible group following chronic social defeat stress (CSDS) exposure, but not in stress-resistant mice. High-frequency stimulation-induced long-term potentiation (LTP) was impaired in the CSDS-induced depression-susceptible group. Further, the levels of pro-brain derived neurotrophic factor (BDNF), mature BDNF, PSD-95, phosphorylated CaMKII, and phosphorylated Cofilin, an actin-filament dynamics regulator, were reduced in CSDS-induced depression-susceptible mice unlike in stress-resistant mice. These results demonstrate that synaptic plasticity-related molecules, such as BDNF and phosphorylated Cofilin, are important for maintaining synaptic functions and structure in mice that experience more stress.

原文English
頁(從 - 到)112-118
頁數7
期刊Biochemical and Biophysical Research Communications
562
DOIs
出版狀態Published - 12 7月 2021

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