Differential effects of age on carotid augmentation index and aortic pulse wave velocity in end-stage renal disease patients

Pai Feng Hsu, Wen Chung Yu, I. Feng Lin, Yao Ping Lin, Shao Yuan Chuang, Hao Min Cheng, Chen Huan Chen

研究成果: Article同行評審

6 引文 斯高帕斯(Scopus)

摘要

Background: In healthy, normotensive individuals, age-related changes in carotid augmentation index (AI) are more prominent in younger individuals (< 50 years), whereas changes in aortic pulse wave velocity (PWV) are more marked in older individuals (> 50 years). We investigated whether the differential effects of age on Al and MAN also existed in endstage renal disease (ESRD) patients. Methods: Two hundred and fifty-seven patients (50% male; mean age, 53.9 ± 15.0 years) with ESRD and 260 normal controls (52% male; mean age, 51.4 ± 17.8 years) received a comprehensive evaluation of cardiovascular structure and function. Results: The percent differences in PWV between the younger and older subjects were similar in both ESRD patients (+46.2%) and normal controls (+52.5%). The percent differences in PWV between normal controls and ESRD patients were also similar in both younger (+28.2%) and older (+22.9%) subjects. In contrast, the differences in AI between the younger and older subjects were small in ESRD patients (7.3%) but large in normal controls (19.7%). Furthermore, there was a large difference in AI between normal controls and ESRD patients in the younger (+13.3%) subjects, but no difference in the older subjects (+0.8%) (interaction between study groups and age: p < 0.001). Conclusion: Markedly differential effects of age on AI and PWV were observed in ESRD patients. PWV increased with age similarly in both ESRD patients and normal controls, whereas AI increased markedly in the younger but only slightly in the older ESRD patients.

原文English
頁(從 - 到)166-173
頁數8
期刊Journal of the Chinese Medical Association
71
發行號4
DOIs
出版狀態Published - 4月 2008

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