Differences in gene mutations according to gender among patients with colorectal cancer

Yi Jian Tsai, Sheng Chieh Huang, Hung Hsin Lin, Chun Chi Lin, Yuan Tzu Lan, Huann Sheng Wang, Shung Haur Yang, Jeng Kai Jiang, Wei Shone Chen, Tzu chen Lin, Jen Kou Lin, Shih Ching Chang*

*此作品的通信作者

研究成果: Article同行評審

17 引文 斯高帕斯(Scopus)

摘要

Background: The incidence, site distribution, and mortality rates of patients with colorectal cancer differ according to gender. We investigated gene mutations in colorectal patients and wanted to examine gender-specific differences. Methods: A total of 1505 patients who underwent surgical intervention for colorectal cancer were recruited from March 2000 to January 2010 at Taipei Veterans' General Hospital and investigated for gene mutations in K-ras, N-ras, H-ras, BRAF, loss of 18q, APC, p53, SMAD4, TGF-β, PIK3CA, PTEN, FBXW7, AKT1, and MSI. Results: There were significant differences between male and female patients in terms of tumor location (p < 0.0001) and pathological stage (p = 0.011). The female patients had significantly more gene mutations in BRAF (6.4 vs. 3.3%, OR 1.985, p = 0.006), TGF-β (4.7 vs. 2.5%, OR 1.887, p = 0.027), and revealed a MSI-high status (14.0 vs. 8.3%, OR 1.800, p = 0.001) than male patients. Male patients had significantly more gene mutations in N-ras (5.1 vs. 2.3%, OR 2.227, p = 0.012); however, the significance was maintained only for mutations in BRAF (OR 2.104, p = 0.038), MSI-high status (OR 2.003 p = 0.001), and N-ras (OR 3.000, p = 0.010) after the groups were divided by tumor site. Conclusion: Gene mutations in BRAF, MSI-high status, and N-ras differ according to gender among patients with colorectal cancer.

原文English
文章編號128
期刊World Journal of Surgical Oncology
16
發行號1
DOIs
出版狀態Published - 5 7月 2018

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