Development of nordihydroguaiaretic acid derivatives as potential multidrug-resistant selective agents for cancer treatment

Lin Chiang Sherlock Huang, Hong Chuang, Mohit Kapoor, Cheng Ying Hsieh, Shih Ching Chou, Hui Hsien Lin, Yi Wei Chen, Chia-Ching Chang, Jih Ru Hwu*, Yu Chuan Liang, Ming Hua Hsu

*此作品的通信作者

研究成果: Article同行評審

7 引文 斯高帕斯(Scopus)

摘要

In this research, we designed and synthesized a new series of nordihydroguaiaretic acid (NDGA) derivatives for multidrug resistance (MDR) research. A methylsulfonyl NDGA derivative, ((2R,3S)-2,3-dimethylbutane-1,4-diyl)bis(benzene-4,1,2-triyl) tetramethanesulfonate (5d), was found to inhibit MDR1 gene expression and suppress drug resistant MES-SA/Dx5 cells. Moreover, the combination of 5d and doxorubicin/terameprocol (M4N) showed a profound synergistic effect on inhibition of drug resistant cancer cells, suggesting that 5d is a potential adjuvant applied with doxorubicin or terameprocol in cancer treatment.

原文English
頁(從 - 到)107833-107838
頁數6
期刊RSC Advances
5
發行號130
DOIs
出版狀態Published - 15 12月 2015

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