Development of Bactericidal Peptides against Multidrug-Resistant Acinetobacter baumannii with Enhanced Stability and Low Toxicity

Prakash Kishore Hazam, Chin Cheng Cheng, Chu Yi Hsieh, Wen Chun Lin, Po Hsien Hsu, Te Li Chen, Yi Tzu Lee, Jyh Yih Chen*

*此作品的通信作者

研究成果: Article同行評審

14 引文 斯高帕斯(Scopus)

摘要

Pathogenic superbugs are the root cause of untreatable complex infections with limited or no treatment options. These infections are becoming more common as clinical antibiotics have lost their effectiveness over time. Therefore, the development of novel antibacterial agents is ur-gently needed to counter these microbes. Antimicrobial peptides (AMPs) are a viable treatment op-tion due to their bactericidal potency against multiple microbial classes. AMPs are naturally selected physiological microbicidal agents that are found in all forms of organisms. In the present study, we developed two tilapia piscidin 2 (TP2)-based AMPs for antimicrobial application. Unlike the parent peptide, the redesigned peptides showed significant antimicrobial activity against multidrug-re-sistant bacterial species. These peptides also showed minimal cytotoxicity. In addition, they were significantly active in the presence of physiological salts, 50% human serum and elevated tempera-ture. The designed peptides also showed synergistic activity when combined with clinical antibiot-ics. The current approach demonstrates a fruitful strategy for developing potential AMPs for anti-microbial application. Such AMPs have potential for progression to further trials and drug development investigations.

原文English
文章編號2191
期刊International Journal Of Molecular Sciences
23
發行號4
DOIs
出版狀態Published - 1 2月 2022

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