摘要
An optical biosensor was developed for choline from a (E)-1-(4-aminophenyl)-3-(4-(dimethylamino)phenyl)prop‑2-en-1-one (4ADP). The biosensor showed strong adsorption of choline in 4ADP with low detection limit of 21 nM was exhibited. This choline sensor 4ADP has been applied to the analysis of choline in serum samples also the binding interaction has been confirmed by NMR titration, FTIR and DFT study. A set of experimental results indicate that the chalcone derivative selectively detects choline in the presence of other biomolecules with 1:1 binding stoichiometry through ICT mechanism.
原文 | English |
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文章編號 | 135040 |
期刊 | Journal of Molecular Structure |
卷 | 1280 |
DOIs | |
出版狀態 | Published - 15 5月 2023 |