Development of an optical biosensor for the determination of choline in human biofluids

Raja Lavanya, Venkatesan Srinivasadesikan, Ming chang Lin, Vediappen Padmini*

*此作品的通信作者

研究成果: Article同行評審

2 引文 斯高帕斯(Scopus)

摘要

An optical biosensor was developed for choline from a (E)-1-(4-aminophenyl)-3-(4-(dimethylamino)phenyl)prop‑2-en-1-one (4ADP). The biosensor showed strong adsorption of choline in 4ADP with low detection limit of 21 nM was exhibited. This choline sensor 4ADP has been applied to the analysis of choline in serum samples also the binding interaction has been confirmed by NMR titration, FTIR and DFT study. A set of experimental results indicate that the chalcone derivative selectively detects choline in the presence of other biomolecules with 1:1 binding stoichiometry through ICT mechanism.

原文English
文章編號135040
期刊Journal of Molecular Structure
1280
DOIs
出版狀態Published - 15 5月 2023

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