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Development of a rapid-onset, acid-labile linkage polyplex-mixed micellar system for anticancer therapy
Shiou Fen Hung
, Yu Han Wen
, Lu Yi Yu
, Hsin Cheng Chiu
, Yi Ting Chiang
*
,
Chun Liang Lo
*
*
此作品的通信作者
生物醫學工程學系
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Keyphrases
Acid-labile Linkage
100%
Acidic Conditions
14%
Acidic Solution
14%
Anticancer Efficiency
14%
Anticancer Therapy
100%
Breakage
14%
Cancer Treatment
14%
Cleavable
14%
Clinal
14%
Confocal Laser Scanning Microscopy
14%
Copolymer
71%
Cytotoxicity
14%
Deprotonated
14%
Endosomal
14%
Endosome
14%
Endosome Escape
28%
Escape Behavior
14%
Focal Adhesion Kinase
28%
HCT116
14%
Histidine
42%
Human Colon Cancer Cell Line
14%
Human Colon Cancer Cells
14%
Hydrophilicity
14%
Hydrophobic Core
14%
Ketal
42%
Lysosomal Degradation
14%
Methacrylate
14%
Methoxy Poly(ethylene glycol)
28%
Micellar Structure
14%
Mixed Micellar System
100%
Mixed Micelles
28%
Oncogenic Proteins
14%
PH-sensitive
14%
Physiological Condition
14%
Poly(methacrylic acid)
14%
Polyanion
14%
Polyethylene Glycol
14%
Polyplex
100%
Protein Expression
14%
Pyridoxal
57%
Pyridoxal Derivative
14%
Rapid Degradation
14%
Rapid Onset
100%
Small Interfering RNA (siRNA)
100%
Pharmacology, Toxicology and Pharmaceutical Science
Acetal
42%
Colon Carcinoma
28%
Confocal Microscopy
14%
Copolymer
71%
Cytotoxicity
14%
Focal Adhesion Kinase
28%
Histidine
42%
Janus Kinase 1
28%
Macrogol
42%
Macrogol Derivative
28%
Methacrylate
14%
Micellar System
100%
Micelle
28%
Poly(methacrylic Acid)
14%
Polyanion
14%
Pyridoxal
71%
Small Interfering RNA
100%
Material Science
Confocal Microscopy
20%
Copolymer
100%
Histidine
60%
Lysosome
20%
Micelle
40%
Polyethylene Glycol
60%
RNA
20%
Chemical Engineering
Copolymer
100%
Polyethylene Glycol
60%