@inproceedings{eb2f83b6cca74e8e9adc42d6330f32f4,
title = "Development of a multisite, closed-loop neuromodulator for the theranosis of neural degenerative diseases",
abstract = "Stimulating specific brain regions has been found useful for treating neural disorders, such as the Parkinson's disease, epilepsy, depression, etc. However, how electrical stimulation modulates neural activities remains not fully understood. As animal models provide the advantage of recording and stimulating different disease-related regions simultaneously, this paper introduces the latest development of a multisite, closed-loop-controlled microsystem for investigating novel treatments on neural degenerative diseases with freely-moving rats. The algorithms for recognizing pathological neural activities automatically are also developed and realized in hardware, so as to control the stimulation in a closed loop and in real time. The pilot studies on the efficacy of treating the Parkinson's disease with closed-loop-controlled stimulation will be presented and discussed. Finally, the feasibility of modelling and probing how neural dynamics and connectivity are modulated by stimulation will be an important topic for future research.",
keywords = "Closed-loop control, Implantable microsystem, Multisite, Neural disorders, Neuromodulation",
author = "Hsin Chen and Chang, {Yen Chung} and Yeh, {Shih Rung} and Hsieh, {Chih Cheng} and Tang, {Kea Tiong} and Hsieh, {Ping Hsuan} and Yu-Te Liao and Ramesh Perumel and Chuang, {Ji Feng} and Chang, {Ching Chih} and Chen, {Yu Chieh} and Chen, {Shih Hsin} and Hsieh, {Sung En} and Chen, {Yen Peng} and Chen, {Ye Ting} and Liu, {Tzu Hao} and Chang, {Yu Ming} and Lai, {Wei Chih} and Wu, {Chuang Yi} and Chen, {Yu Hsin} and Weng, {Yi Chin}",
note = "Publisher Copyright: {\textcopyright} 2018 IEEE.; 38th IEEE Symposium on VLSI Technology, VLSI Technology 2018 ; Conference date: 18-06-2018 Through 22-06-2018",
year = "2018",
month = oct,
day = "25",
doi = "10.1109/VLSIT.2018.8510647",
language = "English",
series = "Digest of Technical Papers - Symposium on VLSI Technology",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
pages = "37--38",
booktitle = "2018 IEEE Symposium on VLSI Technology, VLSI Technology 2018",
address = "美國",
}