Detection of oral early cancerous lesion by using polarization-sensitive optical coherence tomography: Mice model

Hong Yi Lee, Ping Hsien Chen, Tzu Han Lin, Kuo Wei Chang, Wen Chuan Kuo*

*此作品的通信作者

研究成果: Conference contribution同行評審

1 引文 斯高帕斯(Scopus)

摘要

Oral cancer is the 11th most common cancer worldwide, especially in a male adult. The median age of death in oral cancer was 55 years, 10-20 years earlier than other cancers. Presently, oral cancer is often found in late stage, because the lesion is often flat in early stage and is difficult to diagnose under traditional white light imaging. The only definitive method for determining cancer is an invasive biopsy and then using histology examination. How to detect precancerous lesions or early malignant lesions is an important issue for improving prognosis of oral cancer. Optical coherence tomography (OCT) is a new optical tool for diagnosing early malignant lesions in the skin or gastrointestinal tract recently. Here we report a new method for detecting precancerous or early malignant oral lesions by using swept source polarization-sensitive optical coherence tomography (PS-OCT) with center-wavelength 1310 nm, bandwidth 110 nm and 100 kHz swept rate. We used all single-mode fiber design to detect the change of birefringence information in the epithelium structure. This system has an advantage that enables measurement of backscattered intensity and birefringence simultaneously with only one A-scan per transverse location. In preliminary result, we computed the slope of the every A-scan signal in tissue part using a linear-curve fitting in backscattered intensity and birefringence on the enface. In this research, we used an oral cancer mice model for observing the change of structure and birefringence properties in different stages of oral cancer mice. We presented the parametric enface imaging that can detect the early oral malignant lesions.

原文English
主出版物標題Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVI
編輯Tuan Vo-Dinh, Warren S. Grundfest, Anita Mahadevan-Jansen
發行者SPIE
ISBN(電子)9781510614536
DOIs
出版狀態Published - 2018
事件Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVI 2018 - San Francisco, United States
持續時間: 28 1月 201830 1月 2018

出版系列

名字Progress in Biomedical Optics and Imaging - Proceedings of SPIE
10484
ISSN(列印)1605-7422

Conference

ConferenceAdvanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVI 2018
國家/地區United States
城市San Francisco
期間28/01/1830/01/18

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