Detection of discriminative sequence motifs in proteins obtained from prokaryotes grown at various temperatures

Li Cheng Wu, Jorng Tzong Horng*, Shir L.Y. Huang, Hsien D.A. Huang, Baw Jhiune Liu

*此作品的通信作者

研究成果: Article同行評審

1 引文 斯高帕斯(Scopus)

摘要

Recent investigations on the stability of proteins have demonstrated various structural factors, but few have considered sequence factors such as protein motifs. These motifs represent highly conserved regions and describe critical regions that may only exist on proteins that remain functional at high temperatures. This investigation presents a method for identifying and comparing corresponding mesophilic and thermophilic sequence motifs between protein families. Discriminative motifs that are conserved only in the mesophilic or thermophilic subfamily are identified. Analysis of the results shows that, although the subfamilies of most protein families share similar motifs, some discriminative motifs are present in particular thermophilic/mesophilic subfamilies. The thermophilic discriminative motifs are conserved only in thermophilic organisms, revealing that physiochemical principles support thermostability.

原文English
頁(從 - 到)798-808
頁數11
期刊Journal of Computational Chemistry
27
發行號6
DOIs
出版狀態Published - 30 4月 2006

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