The holding voltage of the high-voltage ESD protection devices in snapback breakdown condition has been found to be much smaller than the power supply voltage. Such characteristics will cause the high-voltage CMOS ICs susceptible to the latchup-like danger in the real system applications, especially while these devices are used in the power-rail ESD clamp circuit. A new latchup-free design on the power-rail ESD clamp circuit with stacked-field-oxide structure is proposed and successfully verified in a 0.25-μm 40-V CMOS process to achieve the desired ESD level. The total holding voltage of the stacked-field-oxide structure in snapback breakdown condition can be larger than the power supply voltage. Therefore, latchup or latchup-like issues can be avoided by stacked-field-oxide structures for the IC applications with VDD of 40V.