Design for Restricted-Area and Fast Dilution using Programmable Microfluidic Device based Lab-on-a-Chip

Shuaijie Ying, Sudip Roy, Juinn Dar Huang, Shigeru Yamashita

研究成果: Conference contribution同行評審

摘要

Microfluidic lab-on-a-chip has emerged as a new technology for implementing biochemical protocols on small-sized portable devices targeting low-cost medical diagnostics. Among various efforts of fabrication of such chips, programmable microfluidic device (PMD) is a relatively new technology for implementation of flow-based lab-on-a-chips. A PMD chip is suitable for automation due to its symmetric nature. In order to implement a bioprotocol on such a reconfigurable device, it is crucial to automate sample preparation on a chip as well. Sample preparation, which is a front-end process to produce the desired target concentrations of the input reagent fluid, plays a pivotal role in every bioassay or bioprotocol. In this paper, first, a method referred as dilution algorithm in two steps (DATS) is proposed, which needs only two diluting operations for any target concentration to achieve. Then, we present another method called as dilution algorithm on a small dilution area (DASDA), which needs less area compared to that by DATS. Finally, we propose the heuristic for efficient dilution of biochemical fluids using a PMD chip referred as dilution algorithm in a restricted dilution area (DARDA) that produces more accurate (with less error) target concentration value on a restricted area of the PMD chip in a shorter mixing time. Simulation results reveal that DARDA outperforms a start-of-the-art dilution algorithm applicable for PMD chips in terms of three performance parameters namely mixing time, mixing area and error in target concentration.

原文English
主出版物標題Proceedings - 2021 24th Euromicro Conference on Digital System Design, DSD 2021
編輯Francesco Leporati, Salvatore Vitabile, Amund Skavhaug
發行者Institute of Electrical and Electronics Engineers Inc.
頁面488-494
頁數7
ISBN(電子)9781665427036
DOIs
出版狀態Published - 2021
事件24th Euromicro Conference on Digital System Design, DSD 2021 - Virtual, Online, Italy
持續時間: 1 9月 20213 9月 2021

出版系列

名字Proceedings - 2021 24th Euromicro Conference on Digital System Design, DSD 2021

Conference

Conference24th Euromicro Conference on Digital System Design, DSD 2021
國家/地區Italy
城市Virtual, Online
期間1/09/213/09/21

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