摘要
The present article describes the design and synthesis of new biprivileged molecular scaffolds with diverse structural features. Commercially available, simple heterocyclic building blocks such as 4-fluoro-3-nitrobenzoic acid, 2-chloro-3-nitrobenzoic acid, and indoline were utilized for the synthesis of the novel heterocycles. Pictet-Spengler-type condensation was used as a key step to construct tetracyclic indolo-benzodiazepines and indolo-quinoxalines linked with substituted benzimidazoles. Analysis of single crystals of representative compounds showed that these molecular skeletons have the potential to present various substituents with distinct three-dimensional orientations.
| 原文 | English |
|---|---|
| 頁（從 - 到） | 1684-1690 |
| 頁數 | 7 |
| 期刊 | Chemistry - An Asian Journal |
| 卷 | 7 |
| 發行號 | 7 |
| DOIs | |
| 出版狀態 | Published - 1 6月 2012 |