Defeating antibiotic-resistant bacteria: Exploring alternative therapies for a post-antibiotic era

Chih Hung Wang, Yi Hsien Hsieh, Zachary M. Powers, Cheng Yen Kao*

*此作品的通信作者

研究成果: Review article同行評審

94 引文 斯高帕斯(Scopus)

摘要

Antibiotics are one of the greatest medical advances of the 20th century, however, they are quickly becoming useless due to antibiotic resistance that has been augmented by poor antibiotic stewardship and a void in novel antibiotic discovery. Few novel classes of antibiotics have been discovered since 1960, and the pipeline of antibiotics under development is limited. We therefore are heading for a post-antibiotic era in which common infections become untreatable and once again deadly. There is thus an emergent need for both novel classes of antibiotics and novel approaches to treatment, including the repurposing of existing drugs or preclinical compounds and expanded implementation of combination therapies. In this review, we highlight to utilize alternative drug targets/therapies such as combinational therapy, anti-regulator, anti-signal transduction, anti-virulence, anti-toxin, engineered bacteriophages, and microbiome, to defeat antibiotic-resistant bacteria.

原文English
文章編號1061
期刊International Journal Of Molecular Sciences
21
發行號3
DOIs
出版狀態Published - 1 2月 2020

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