dbPTM: an information repository of protein post-translational modification.

Tzong Yi Lee*, Hsien Da Huang, Jui-Hung Hung, Hsi Yuan Huang, Yuh-Shyong Yang, Tzu Hao Wang

*此作品的通信作者

研究成果: Article同行評審

174 引文 斯高帕斯(Scopus)

摘要

dbPTM is a database that compiles information on protein post-translational modifications (PTMs), such as the catalytic sites, solvent accessibility of amino acid residues, protein secondary and tertiary structures, protein domains and protein variations. The database includes all of the experimentally validated PTM sites from Swiss-Prot, PhosphoELM and O-GLYCBASE. Only a small fraction of Swiss-Prot proteins are annotated with experimentally verified PTM. Although the Swiss-Prot provides rich information about the PTM, other structural properties and functional information of proteins are also essential for elucidating protein mechanisms. The dbPTM systematically identifies three major types of protein PTM (phosphorylation, glycosylation and sulfation) sites against Swiss-Prot proteins by refining our previously developed prediction tool, KinasePhos (http://kinasephos.mbc.nctu.edu.tw/). Solvent accessibility and secondary structure of residues are also computationally predicted and are mapped to the PTM sites. The resource is now freely available at http://dbPTM.mbc.nctu.edu.tw/.

原文English
頁(從 - 到)D622-D627
期刊Nucleic acids research
34
發行號Database issue
DOIs
出版狀態Published - 1 一月 2006

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